ReviewMedical microbiology and immunology2007
The threat of avian influenza A (H5N1). Part IV: Development of vaccines.
Review in Medical microbiology and immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00488046 (Phase I Inpatient Study of the Safety and Immunogenicity of Live Influenza A Vaccine Modified H5N1), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase I Inpatient Study of the Safety and Immunogenicity of Live Influenza A Vaccine Modified H5N1 (6-2) AA ca Recombinant (A/Hong Kong/213/2003 x A/AnnArbor/6/60 ca), a Live Attenuated Virus Vaccine Candidate for Prevention of Avian Influenza H5N1 Infection in the Event of a Pandemic
Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Inhibitory Activity of Honeysuckle Extracts against Influenza A Virus In Vitro and In Vivo.Virologica Sinica · 2021Article
- High accumulation in tobacco seeds of hemagglutinin antigen from avian (H5N1) influenza.Transgenic research · 2017Article
- Vaccination against infectious diseases: what is promising?Medical microbiology and immunology · 2014Review
- N-acetyl-l-cystine (NAC) protects against H9N2 swine influenza virus-induced acute lung injury.International immunopharmacology · 2014Article
- Recent publications in medical microbiology and immunology: a retrospective.Medical microbiology and immunology · 2012Review
- DNA aptamers against the receptor binding region of hemagglutinin prevent avian influenza viral infection.Molecules and cells · 2011Article
- Article
- Glycyrrhizin inhibits highly pathogenic H5N1 influenza A virus-induced pro-inflammatory cytokine and chemokine expression in human macrophages.Medical microbiology and immunology · 2010Article
- Possible hidden hazards of mass vaccination against new influenza A/H1N1: have the cardiovascular risks been adequately weighed?Medical microbiology and immunology · 2009Article
- An influenza A H1N1 virus revival - pandemic H1N1/09 virus.Infection · 2009Review
- Seroprevalence of influenza A and B in German infants and adolescents.Medical microbiology and immunology · 2009Article
- A gene-based avian influenza vaccine in poultry.Poultry science · 2009Article
- Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses.Nature structural & molecular biology · 2009Article
- Respiratory tract infections and pneumonia.Periodontology 2000 · 2009Review
- Incorporation of membrane-anchored flagellin into influenza virus-like particles enhances the breadth of immune responses.Journal of virology · 2008Article
- New pre-pandemic influenza vaccines: an egg- and adjuvant-independent human adenoviral vector strategy induces long-lasting protective immune responses in mice.Clinical pharmacology and therapeutics · 2007Article
- Two novel HLA-A*0201 T-cell epitopes in avian H5N1 viral nucleoprotein induced specific immune responses in HHD mice.Veterinary researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among emerging and re-emerging infectious diseases, influenza constitutes one of the major threats to mankind. In this review series epidemiologic, virologic and pathologic concerns raised by infections of humans with avian influenza virus A/H5N1 are discussed. This fourth part focuses on vaccine development. Several phase I clinical studies with vaccines against H5 viruses have demonstrated limited efficacy compared to seasonal influenza vaccines. To induce protective immunity two immunisations with increased amounts of H5N1 vaccine were required. Novel vaccination strategies that are egg- and adjuvant-independent, broadly cross-reactive and long-lasting are highly desirable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.