ReviewPflugers Archiv : European journal of physiology2007
The lipid connection-regulation of voltage-gated Ca(2+) channels by phosphoinositides.
Review in Pflugers Archiv : European journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Cross-Talk Between the Adenylyl Cyclase/cAMP Pathway and CaReviews of physiology, biochemistry and pharmacology · 2021Review
- PIPPhysiological reports · 2019Article
- Article
- Molecular Basis of the Membrane Interaction of the β2e Subunit of Voltage-Gated Ca(2+) Channels.Biophysical journal · 2015Article
- A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.The Journal of biological chemistry · 2015Article
- The active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels.eLife · 2015Article
- Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels.Annual review of physiology · 2015Review
- Regulation of Ca(V)2 calcium channels by G protein coupled receptors.Biochimica et biophysica acta · 2013Review
- Phosphoinositides: tiny lipids with giant impact on cell regulation.Physiological reviews · 2013Review
- Structure and function of the β subunit of voltage-gated Ca²⁺ channels.Biochimica et biophysica acta · 2013Review
- Membrane-localized β-subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Restoration of defective L-type Ca2+ current in cardiac myocytes of type 2 diabetic db/db mice by Akt and PKC-ι.Journal of cardiovascular pharmacology · 2011Article
- Neuronal calcium sensor-1 regulation of calcium channels, secretion, and neuronal outgrowth.Cellular and molecular neurobiology · 2010Review
- The ß subunit of voltage-gated Ca2+ channels.Physiological reviews · 2010Review
- Modulation of high-voltage activated Ca(2+) channels by membrane phosphatidylinositol 4,5-bisphosphate.Neuron · 2010Article
- Channelopathies linked to plasma membrane phosphoinositides.Pflugers Archiv : European journal of physiology · 2010Review
- Multiple muscarinic pathways mediate the suppression of voltage-gated Ca2+ channels in mouse intestinal smooth muscle cells.British journal of pharmacology · 2009Article
- The Ca2+ channel beta subunit determines whether stimulation of Gq-coupled receptors enhances or inhibits N current.The Journal of general physiology · 2009Article
- An oily competition: role of beta subunit palmitoylation for Ca2+ channel modulation by fatty acids.The Journal of general physiology · 2009Article
- Phosphoinositide signaling: new tools and insights.Physiology (Bethesda, Md.) · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent findings have revealed a pivotal role for phospholipids phosphatidylinositol -4,5-biphosphate (PIP(2)) and phosphatidylinositol -3,4,5-trisphosphate (PIP(3)) in the regulation of high voltage-activated (HVA) Ca(2+) channels. PIP(2) exerts two opposing actions on HVA Ca(2+) channels: It stabilizes their activity but also produces a voltage-dependent inhibition that can be antagonized by protein kinase A (PKA) phosphorylation. PIP(2) depletion and arachidonic acid together mediate the slow, voltage-independent inhibition of HVA Ca(2+) channels by G( q/11 )-coupled receptors in neurons. A sufficient level of plasma membrane PIP(2) also appears to be necessary for G( betagamma )-mediated inhibition. On the other hand, increased production of PIP(3) by PI-3 kinases promotes trafficking of HVA Ca(2+) channels to the plasma membrane. This review discusses these findings and their implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.