ArticleIntensive care medicine2007
Association of cell-free plasma DNA with hospital mortality and organ dysfunction in intensive care unit patients.
Article in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- The role of total cell-free DNA in predicting outcomes among trauma patients in the intensive care unit: a systematic review.Critical care (London, England) · 2017Pooled it
- Diagnosis and surgical management of septic peritonitis in small animals: A review.Veterinary surgery : VS · 2026Review
- Cell-free DNA predicts all-cause mortality of sepsis-induced acute kidney injury.Renal failure · 2024Article
- Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma.Scientific reports · 2021Article
- Urinary cell-free mitochondrial and nuclear deoxyribonucleic acid correlates with the prognosis of chronic kidney diseases.BMC nephrology · 2019Article
- Article
- Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids.Cell death and differentiation · 2019Review
- Response to: A brief comment on the predictive value of myeloperoxidase-conjugated DNA level in patients with septic shock.Critical care (London, England) · 2018Article
- The Role of Danger Signals in the Pathogenesis and Perpetuation of Critical Illness.American journal of respiratory and critical care medicine · 2018Review
- Development and Evaluation of a Duplex Real-Time PCR Assay With a Novel Internal Standard for Precise Quantification of Plasma DNA.Annals of laboratory medicine · 2017Article
- Emerging infection and sepsis biomarkers: will they change current therapies?Expert review of anti-infective therapy · 2016Review
- Cell-free DNA increase over first 48 hours in emergency intensive care unit predicts fatal outcome in patients with shock.The Journal of international medical research · 2016Observational
- Peritoneal Cell-free DNA: an innovative method for determining acute cell damage in peritoneal membrane and for monitoring the recovery process after peritonitis.Journal of nephrology · 2016Article
- Urinary Biomarkers Indicative of Apoptosis and Acute Kidney Injury in the Critically Ill.PloS one · 2016Observational
- Combination of cyclophosphamide and double-stranded DNA demonstrates synergistic toxicity against established xenografts.Cancer cell international · 2015Article
- Biomarkers for Sepsis: What Is and What Might Be?Biomarker insights · 2015Review
- Prognostic and diagnostic value of eosinopenia, C-reactive protein, procalcitonin, and circulating cell-free DNA in critically ill patients admitted with suspicion of sepsis.Critical care (London, England) · 2014Article
- The role of cell-free DNA measured by a fluorescent test in the management of isolated traumatic head injuries.Scandinavian journal of trauma, resuscitation and emergency medicine · 2014Observational
- High cell-free DNA predicts fatal outcome among Staphylococcus aureus bacteraemia patients with intensive care unit treatment.PloS one · 2014Article
- Cell-free DNA as a potential marker to predict carbon tetrachloride-induced acute liver injury in rats.Hepatology international · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the concentration of cell-free plasma DNA and its association with organ dysfunction and hospital mortality in intensive care unit patients. DESIGN AND
settingProspective cohort study in a medical and two medical-surgical intensive care units in a university hospital. PATIENTS: 228 critically ill patients admitted to the ICUs between January 2004 and July 2005. MEASUREMENTS AND
resultsBlood samples were collected as soon as possible after ICU admission, the following morning, and 48[Symbol: see text]h after the second sample. The cell-free plasma DNA was measured by real-time quantitative PCR assay for the beta-globin gene. Physiological and mortality data were collected to the clinical database. Hospital mortality rate and SOFA scores were primary outcome measures. The maximum plasma DNA concentrations were correlated significantly with APACHE II points and with maximum SOFA scores. Cell-free plasma DNA concentrations were higher in hospital non-survivors than in survivors (median 9,366 vs. 6,506 GE/ml). Using logistic regression analysis, the maximum plasma DNA was an independent predictor of hospital mortality.
conclusionsThe maximum plasma DNA concentration measured during the first 96[Symbol: see text]h of intensive care is associated with the degree of organ dysfunction and disease severity. Moreover, the maximum DNA concentration is independently associated with hospital mortality.
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