ArticleJournal of biomedicine & biotechnology2007
Stem cell fate analysis revisited: interpretation of individual clone dynamics in the light of a new paradigm of stem cell organization.
Article in Journal of biomedicine & biotechnology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- A mixed-effects stochastic model reveals clonal dominance in gene therapy safety studies.BMC bioinformatics · 2023Article
- Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis.BMC systems biology · 2013Article
- A review of spatial computational models for multi-cellular systems, with regard to intestinal crypts and colorectal cancer development.Journal of mathematical biology · 2013Review
- Bone marrow mesenchymal stem cells differentiate into urothelial cells and the implications for reconstructing urinary bladder mucosa.Cytotechnology · 2011Article
- A novel validation algorithm allows for automated cell tracking and the extraction of biologically meaningful parameters.PloS one · 2011Article
- Enabling stem cell therapies through synthetic stem cell-niche engineering.The Journal of clinical investigation · 2010Review
- Cell lineages and the logic of proliferative control.PLoS biology · 2009Article
- Article
- Noise-driven stem cell and progenitor population dynamics.PloS one · 2008Article
- Multiway modeling and analysis in stem cell systems biology.BMC systems biology · 2008Article
- Insertional mutagenesis and clonal dominance: biological and statistical considerations.Gene therapy · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many experimental findings on heterogeneity, flexibility, and plasticity of tissue stem cells are currently challenging stem cell concepts that assume a cell intrinsically predefined, unidirectional differentiation program. In contrast to these classical concepts, nonhierarchical self-organizing systems provide an elegant and comprehensive alternative to explain the experimental data. Here we present the application of such a self-organizing concept to quantitatively describe the hematopoietic stem cell system. Focusing on the analysis of individual-stem-cell fates and clonal dynamics, we particularly discuss implications of the theoretical results on the interpretation of experimental findings. We demonstrate that it is possible to understand hematopoietic stem cell organization without assumptions on unidirectional developmental hierarchies, preprogrammed asymmetric division events or other assumptions implying the existence of a predetermined stem cell entity. The proposed perspective, therefore, changes the general paradigm of thinking about stem cells.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.