ArticleDevelopmental biology2007
PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 61 citations in OpenAlex.
- Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signaling.bioRxiv : the preprint server for biology · 2026Article
- Developmental Hypoxia Enhances Kidney Organoid Complexity and Maturity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Loss of Myo19 increases metastasis by enhancing microenvironmental ROS gradient and chemotaxis.EMBO reports · 2024Article
- Targeting the RET tyrosine kinase in neuroblastoma: A review and application of a novel selective drug design strategy.Biochemical pharmacology · 2023Review
- Review
- Hallmarks of RET and Co-occuring Genomic Alterations inMolecular cancer therapeutics · 2021Review
- Organ-Specific Branching Morphogenesis.Frontiers in cell and developmental biology · 2021Review
- Advances in understanding vertebrate nephrogenesis.Tissue barriers · 2020Article
- FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.Developmental cell · 2019Article
- Regulation of Renal Differentiation by Trophic Factors.Frontiers in physiology · 2018Review
- The GDNF Family: A Role in Cancer?Neoplasia (New York, N.Y.) · 2018Review
- Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8.Journal of the American Society of Nephrology : JASN · 2016Article
- Proteomic analysis of embryonic kidney development: Heterochromatin proteins as epigenetic regulators of nephrogenesis.Scientific reports · 2015Article
- Phosphatidylinositol 3-kinase signaling determines kidney size.The Journal of clinical investigation · 2015Article
- The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through β-catenin signaling.Stem cell reports · 2015Article
- Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling.Journal of signal transduction · 2015Review
- Renin-angiotensin system in ureteric bud branching morphogenesis: implications for kidney disease.Pediatric nephrology (Berlin, Germany) · 2014Review
- Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion.PLoS genetics · 2014Article
- Article
- The genetics and epigenetics of kidney development.Seminars in nephrology · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The RET receptor tyrosine kinase is activated by GDNF and controls outgrowth and invasion of the ureteric bud epithelia in the developing kidney. In renal epithelial cells and in enteric neuronal precursor cells, activation of RET results in chemotaxis as Ret expressing cells invade the surrounding GDNF expressing tissue. One potential downstream signaling pathway governing RET mediated chemotaxis may require phosphatidylinositol 3-kinase (PI3K), which generates PI(3,4,5) triphosphate. The PTEN tumor suppressor gene encodes a protein and lipid phosphatase that regulates cell growth, apoptosis and many other cellular processes. PTEN helps regulate cellular chemotaxis by antagonizing the PI3K signaling pathway through dephosphorylation of phosphotidylinositol triphosphates. In this report, we show that PTEN suppresses RET mediated cell migration and chemotaxis in cell culture assays, that RET activation results in asymmetric localization of inositol triphosphates and that loss of PTEN affects the pattern of branching morphogenesis in developing mouse kidneys. These data suggest a critical role for the PI3K/PTEN axis in shaping the pattern of epithelial branches in response to RET activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.