ReviewWorld journal of surgical oncology2007
Precursors and preinvasive lesions of the breast: the role of molecular prognostic markers in the diagnostic and therapeutic dilemma.
Review in World journal of surgical oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Identification of aberrant gene expression during breast ductal carcinomaThe Journal of international medical research · 2020Article
- Article
- Biomarkers expression in benign breast diseases and risk of subsequent breast cancer: a case-control study.Cancer medicine · 2017Article
- Bioanalytical LC-MS Method for the Quantification of Plasma Androgens and Androgen Glucuronides in Breast Cancer.Journal of chromatographic science · 2016Article
- Gene expression profiling of mammary glands at an early stage of DMBA-induced carcinogenesis in the female Sprague-Dawley rat.European journal of oncology = Giornale europeo di oncologia · 2016Article
- Emerging role of cell polarity proteins in breast cancer progression and metastasis.Breast cancer (Dove Medical Press) · 2014Review
- Prognostic value of molecular markers and cytogenetic alterations that characterize breast cancer precursor lesions (Review).Oncology letters · 2013Article
- Comparative analysis of loss of heterozygosity and expression profile in normal tissue, DCIS and invasive breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2011Article
- p53 nuclear accumulation and ERalpha expression in ductal hyperplasia of breast in a cohort of 215 Chinese women.Journal of experimental & clinical cancer research : CR · 2010Article
- Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions.BMC cancer · 2010Article
- Histological type and grade of breast cancer tumors by parity, age at birth, and time since birth: a register-based study in Norway.BMC cancer · 2010Article
- Heat shock protein90 in lobular neoplasia of the breast.BMC cancer · 2008Article
- The role of radiotherapy in the conservative treatment of ductal carcinoma in situ of the breast.Pathology oncology research : POR · 2008Review
- Immunohistochemical expression of estrogen receptors alpha and beta in lobular neoplasia.Virchows Archiv : an international journal of pathology · 2007Article
- HER2/NEU GENE EXPRESSION PRODUCTS EVALUATED WITH SUPERPARAMAGNETIC, GENETICALLY ENGINEERED ANTIBODIES.Proceedings of the South Dakota Academy of Science · 2007Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Precursors and preinvasive lesions of the breast include atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and lobular neoplasia (LN). There is a significant debate regarding the classification, diagnosis, prognosis and management of these lesions. This review article describes the current theories regarding the pathogenesis and molecular evolution of these lesions. It reviews the implication of a variety of molecules in the continuum of breast lesions: estrogen receptors (ER-alpha and ER-beta), c-erb-B2 (Her2/neu), p53, Ki-67, bcl-2, E-cadherin, transforming growth factor-beta (TGF-beta), p27 (Kip1), p16 (INK4a), p21 (Waf1), vascular endothelial growth factor (VEGF). With respect to the aforementioned molecules, this article reviews their pathophysiological importance, and puts the stress on whether they confer additional risk for invasive breast cancer or not. This knowledge has the potential to be of importance in the therapeutic decisions presenting in the common clinical practice.
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