ArticleBMC developmental biology2007
BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo.
Article in BMC developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- BDNF Signaling in Glutamatergic Neurons During Long-Term Potentiation (LTP): A Spatio-Temporal Exploration of Events.Molecular neurobiology · 2025Review
- Innovations in spinal cord cell type heterogeneity across vertebrate evolution.bioRxiv : the preprint server for biology · 2025Article
- Development of a heat-stable alkaline phosphatase reporter system for cis-regulatory analysis and its application to 3D digital imaging of Xenopus embryonic tissues.Development, growth & differentiation · 2024Article
- BDNF and NGF signals originating from sensory ganglia promote cranial motor axon growth.Experimental brain research · 2020Article
- Review
- Histone deacetylase activity has an essential role in establishing and maintaining the vertebrate neural crest.Development (Cambridge, England) · 2018Article
- Regulation of ECM degradation and axon guidance by growth cone invadosomes.Development (Cambridge, England) · 2015Article
- Heparanase 2, mutated in urofacial syndrome, mediates peripheral neural development in Xenopus.Human molecular genetics · 2014Article
- Article
- Neurogenesis is required for behavioral recovery after injury in the visual system of Xenopus laevis.The Journal of comparative neurology · 2013Article
- pTransgenesis: a cross-species, modular transgenesis resource.Development (Cambridge, England) · 2011Article
- Characterisation of a new regulator of BDNF signalling, Sprouty3, involved in axonal morphogenesis in vivo.Development (Cambridge, England) · 2010Article
- The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching.Nature neuroscience · 2010Article
- Conservation, development, and function of a cement gland-like structure in the fish Astyanax mexicanus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Brain-derived neurotrophic factor and the development of structural neuronal connectivity.Developmental neurobiology · 2010Review
- Myosin-X is required for cranial neural crest cell migration in Xenopus laevis.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Contactin 1 knockdown in the hindbrain induces abnormal development of the trigeminal sensory nerve in Xenopus embryos.Development genes and evolution · 2007Article
- Journey to the skin: Somatosensory peripheral axon guidance and morphogenesis.Cell adhesion & migrationReview
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundTrigeminal nerves consist of ophthalmic, maxillary, and mandibular branches that project to distinct regions of the facial epidermis. In Xenopus embryos, the mandibular branch of the trigeminal nerve extends toward and innervates the cement gland in the anterior facial epithelium. The cement gland has previously been proposed to provide a short-range chemoattractive signal to promote target innervation by mandibular trigeminal axons. Brain derived neurotrophic factor, BDNF is known to stimulate axon outgrowth and branching. The goal of this study is to determine whether BDNF functions as the proposed target recognition signal in the Xenopus cement gland.
resultsWe found that the cement gland is enriched in BDNF mRNA transcripts compared to the other neurotrophins NT3 and NT4 during mandibular trigeminal nerve innervation. BDNF knockdown in Xenopus embryos or specifically in cement glands resulted in the failure of mandibular trigeminal axons to arborise or grow into the cement gland. BDNF expressed ectodermal grafts, when positioned in place of the cement gland, promoted local trigeminal axon arborisation in vivo.
conclusionBDNF is necessary locally to promote end stage target innervation of trigeminal axons in vivo, suggesting that BDNF functions as a short-range signal that stimulates mandibular trigeminal axon arborisation and growth into the cement gland.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.