ArticleJournal of the American Society of Nephrology : JASN2007
Role of gp91phox -containing NADPH oxidase in mediating the effect of K restriction on ROMK channels and renal K excretion.
Article in Journal of the American Society of Nephrology : JASN, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Mechanistic target of rapamycin complex-1 plays a role in inhibiting kidney KAmerican journal of physiology. Renal physiology · 2026Article
- Mechanistic target of rapamycin complex-2 mediates the effect of overnight high KAmerican journal of physiology. Renal physiology · 2026Article
- NADPH oxidases: redox regulation of cell homeostasis and disease.Physiological reviews · 2025Review
- Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase.American journal of physiology. Renal physiology · 2024Article
- Differential contribution of Nox1, Nox2 and Nox4 to kidney vascular oxidative stress and endothelial dysfunction in obesity.Redox biology · 2020Article
- PGFAmerican journal of physiology. Renal physiology · 2017Article
- Role for reactive oxygen species in flow-stimulated inner medullary collecting duct endothelin-1 production.American journal of physiology. Renal physiology · 2017Article
- Effects of Reactive Oxygen Species on Tubular Transport along the Nephron.Antioxidants (Basel, Switzerland) · 2017Review
- Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits.Physiology (Bethesda, Md.) · 2017Review
- Caveolin-1 Deficiency Inhibits the Basolateral K+ Channels in the Distal Convoluted Tubule and Impairs Renal K+ and Mg2+ Transport.Journal of the American Society of Nephrology : JASN · 2015Article
- Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect.American journal of physiology. Renal physiology · 2014Article
- Article
- NADPH oxidases, reactive oxygen species, and the kidney: friend and foe.Journal of the American Society of Nephrology : JASN · 2013Review
- Angiotensin II stimulates basolateral 10-pS Cl channels in the thick ascending limb.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Gut sensing of potassium intake and its role in potassium homeostasis.Seminars in nephrology · 2013Review
- Direct activation of ENaC by angiotensin II: recent advances and new insights.Current hypertension reports · 2013Review
- Angiotensin II stimulates epithelial sodium channels in the cortical collecting duct of the rat kidney.American journal of physiology. Renal physiology · 2012Article
- Cyp2c44 epoxygenase is essential for preventing the renal sodium absorption during increasing dietary potassium intake.Hypertension (Dallas, Tex. : 1979) · 2012Article
- NAD(P)H oxidase and renal epithelial ion transport.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Review
- Decrease in dietary K intake stimulates the generation of superoxide anions in the kidney and inhibits K secretory channels in the CCD.American journal of physiology. Renal physiology · 2010Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Previous study has demonstrated that superoxide and the related products are involved in mediating the effect of low K intake on renal K secretion and ROMK channel activity in the cortical collecting duct (CCD). This study investigated the role of gp91(phox)-containing NADPH oxidase (NOXII) in mediating the effect of low K intake on renal K excretion and ROMK channel activity in gp91(-/-) mice. K depletion increased superoxide levels, phosphorylation of c-Jun, expression of c-Src, and tyrosine phosphorylation of ROMK in renal cortex and outer medulla in wild-type (WT) mice. In contrast, tempol treatment in WT mice abolished whereas deletion of gp91 significantly attenuated the effect of low K intake on superoxide production, c-Jun phosphorylation, c-Src expression, and tyrosine phosphorylation of ROMK. Patch-clamp experiments demonstrated that low K intake decreased mean product of channel number (N) and open probability (P) (NP(o)) of ROMK channels from 1.1 to 0.4 in the CCD. However, the effect of low K intake on ROMK channel activity was significantly attenuated in the CCD from gp91(-/-) mice and completely abolished by tempol treatment. Immunocytochemical staining also was used to examine the ROMK distribution in WT, gp91(-/-), and WT mice with tempol treatment in response to K restriction. K restriction decreased apical staining of ROMK in WT mice. In contrast, a sharp apical ROMK staining was observed in the tempol-treated WT or gp91(-/-) mice. Metabolic cage study further showed that urinary K loss is significantly higher in gp91(-/-) mice than in WT mice. It is concluded that superoxide anions play a key role in suppressing K secretion during K restriction and that NOXII is involved in mediating the effect of low K intake on renal K secretion and ROMK channel activity.
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