ArticleMolecular biology of the cell2007
Evidence that mono-ADP-ribosylation of CtBP1/BARS regulates lipid storage.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
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- Delayed recruiting of TPD52 to lipid droplets - evidence for a "second wave" of lipid droplet-associated proteins that respond to altered lipid storage induced by Brefeldin A treatment.Scientific reports · 2019Article
- ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2.Cytoskeleton (Hoboken, N.J.) · 2017Article
- CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors.Cancer biology & therapy · 2017Review
- Comparative proteomics reveals abnormal binding of ATGL and dysferlin on lipid droplets from pressure overload-induced dysfunctional rat hearts.Scientific reports · 2016Article
- Article
- Lipid Droplets as Signaling Platforms Linking Metabolic and Cellular Functions.Lipid insights · 2014Article
- Dynamics and molecular determinants of cytoplasmic lipid droplet clustering and dispersion.PloS one · 2013Article
- Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny.PLoS pathogens · 2013Article
- Identification of diverse lipid droplet targeting motifs in the PNPLA family of triglyceride lipases.PloS one · 2013Article
- Review
- Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol.The Journal of biological chemistry · 2011Article
- Role for ADP ribosylation factor 1 in the regulation of hepatitis C virus replication.Journal of virology · 2011Article
- Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets.Journal of cell science · 2009Article
- The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.Molecular and cellular biology · 2008Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Mono-ADP-ribosylation is emerging as an important posttranslational modification that modulates a variety of cell signaling pathways. Here, we present evidence that mono-ADP-ribosylation of the transcriptional corepressor C terminal binding protein, brefeldin A (BFA)-induced ADP-ribosylated substrate (CtBP1/BARS) regulates neutral lipid storage in droplets that are surrounded by a monolayer of phospholipid and associated proteins. CtBP1/BARS is an NAD-binding protein that becomes ribosylated when cells are exposed to BFA. Both endogenous lipid droplets and droplets enlarged by oleate treatment are lost after 12-h exposure to BFA. Lipid loss requires new protein synthesis, and it is blocked by multiple ribosylation inhibitors, but it is not stimulated by disruption of the Golgi apparatus or the endoplasmic reticulum unfolded protein response. Small interfering RNA knockdown of CtBP1/BARS mimics the effect of BFA, and mouse embryonic fibroblasts derived from embryos that are deficient in CtBP1/BARS seem to be defective in lipid accumulation. We conclude that mono-ADP-ribosylation of CtBP1/BARS inactivates its repressor function, which leads to the activation of genes that regulate neutral lipid storage.
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