ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Rapid synapse elimination after postsynaptic protein synthesis inhibition in vivo.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Dietary nitrate supplementation mitigates age-related changes at the neuromuscular junction in mice.The Journal of physiology · 2026Article
- Emerging role of TAK1 in the regulation of skeletal muscle mass.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Review
- C-terminal agrin fragment as a biomarker of muscle wasting and weakness: a narrative review.Journal of cachexia, sarcopenia and muscle · 2023Review
- The Cellular and Molecular Signature of ALS in Muscle.Journal of personalized medicine · 2022Review
- Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans.The Journal of physiology · 2021Article
- Skeletal muscle mTORC1 regulates neuromuscular junction stability.Journal of cachexia, sarcopenia and muscle · 2020Article
- The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player?Frontiers in molecular neuroscience · 2020Review
- The Role of Dynamic miRISC During Neuronal Development.Frontiers in molecular biosciences · 2020Review
- Sarcopenia: Aging-Related Loss of Muscle Mass and Function.Physiological reviews · 2019 · on this mapReview
- Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning.Neurobiology of learning and memory · 2017Article
- Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The differential role of cortical protein synthesis in taste memory formation and persistence.NPJ science of learning · 2016Article
- Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis.The Journal of clinical investigation · 2013Article
- Intracortical excitatory and thalamocortical boutons are intact in primary auditory cortex in schizophrenia.Schizophrenia research · 2013Article
- The role of glial cells in synapse elimination.Current opinion in neurobiology · 2012Review
- Emerging roles of the neuronal nucleolus.Trends in neurosciences · 2012Review
- Article
- Reversing the outcome of synapse elimination at developing neuromuscular junctions in vivo: evidence for synaptic competition and its mechanism.PLoS biology · 2012Article
- Nerve terminal growth remodels neuromuscular synapses in mice following regeneration of the postsynaptic muscle fiber.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Regulation of synaptic stability by AMPA receptor reverse signaling.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the role of retrograde signals on synaptic maintenance, we inhibited protein synthesis in individual postsynaptic cells in vivo while monitoring presynaptic terminals. Within 12 h, axon terminals begin to atrophy and withdraw from normal postsynaptic sites. Structural similarities between this process and naturally occurring synapse elimination suggest that short-lived target derived factors not only participate in synaptic maintenance in adults, but also regulate elimination of connections during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.