ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Learning-induced survival of new neurons depends on the cognitive status of aged rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 120 citations in OpenAlex.
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- p27, The Cell Cycle and Alzheimer´s Disease.International journal of molecular sciences · 2022Review
- The CBP KIX domain regulates long-term memory and circadian activity.BMC biology · 2020Article
- Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging.Aging cell · 2020Article
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- Adult-generated neurons born during chronic social stress are uniquely adapted to respond to subsequent chronic social stress.Molecular psychiatry · 2019Article
- The Role of SVZ Stem Cells in Glioblastoma.Cancers · 2019Review
- Indomethacin Increases Neurogenesis across Age Groups and Improves Delayed Probe Trial Difference Scores in Middle-Aged Rats.Frontiers in aging neuroscience · 2017Article
- Selective Inactivation of Fibroblast Growth Factor 22 (FGF22) in CA3 Pyramidal Neurons Impairs Local Synaptogenesis and Affective Behavior Without Affecting Dentate Neurogenesis.Frontiers in synaptic neuroscience · 2017Article
- Lupus brain fog: a biologic perspective on cognitive impairment, depression, and fatigue in systemic lupus erythematosus.Immunologic research · 2015Review
- Interaction between Neurogenesis and Hippocampal Memory System: New Vistas.Cold Spring Harbor perspectives in biology · 2015Review
- Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation.Scientific reports · 2015Article
- Regulation and function of adult neurogenesis: from genes to cognition.Physiological reviews · 2014Review
- Activity-dependent signaling mechanisms regulating adult hippocampal neural stem cells and their progeny.Neuroscience bulletin · 2014Review
- Unlocking epigenetic codes in neurogenesis.Genes & development · 2014Review
- A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats.Neuropharmacology · 2014Article
- Role of adult neurogenesis in hippocampal-cortical memory consolidation.Molecular brain · 2014Review
- Environmental enrichment and the sensory brain: the role of enrichment in remediating brain injury.Frontiers in systems neuroscience · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is accompanied by an alteration of spatial memory, which has been related to an alteration in hippocampal plasticity. Within the dentate gyrus, new neurons are generated throughout the entire life of an individual. This neurogenesis seems to play a role in hippocampal-mediated learning and learning-induced changes in neurogenesis have been proposed to be involved in memory. However, in aged rats, little is known on the influence of learning on the early development of the adult-born neurons and on the possible involvement of learning-induced changes in neurogenesis in age-related memory deficits. To address this issue, we took advantage of the existence of spontaneous individual differences for performances observed in aged subjects in the water maze. In this task, learning can be divided into two phases, an early phase during which performances quickly improve, and a late phase during which asymptotic levels of performances are reached. We show that the influence of spatial learning on the survival of the newly born cells depends on their birth date and the memory abilities of the aged rats. In aged rats with preserved spatial memory, learning increases the survival of cells generated before learning whereas it decreases survival of cells produced during the early phase of learning. These results highlight the importance of learning-induced changes in adult-born cell survival in memory. Furthermore, they provide new insights on the possible neural mechanisms of aging of cognitive functions and show that an alteration to the steps leading to neurogenesis may be involved in the determination of individual memory abilities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.