ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Different mechanisms generate maintained activity in ON and OFF retinal ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.
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Who cites it
128 citing papers in PubMed, 219 citations in OpenAlex.
- Article
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- A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness.The Journal of general physiology · 2025Article
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell.The Journal of physiology · 2025Article
- Bursts from the past: Intrinsic properties link a network model to zebra finch song.bioRxiv : the preprint server for biology · 2025Article
- Asymmetric activation of retinal ON and OFF pathways by AOSLO raster-scanned visual stimuli.Biomedical optics express · 2025Article
- Task-specific regional circuit adaptations in distinct mouse retinal ganglion cells.Science advances · 2025Article
- Molecular mechanism establishing the OFF pathway in vision.Nature communications · 2025Article
- Differential Intrinsic Firing Properties in Sustained and Transient Mouse αRGCs Match Their Light Response Characteristics and Persist during Retinal Degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Review
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- Nanoparticle-based optical interfaces for retinal neuromodulation: a review.Frontiers in cellular neuroscience · 2024Review
- Orchestrating Blood Flow in the Retina: Interpericyte Tunnelling Nanotube Communication.Results and problems in cell differentiation · 2024Review
- Transient and Sustained Ganglion Cell Light Responses Are Differentially Modulated by Intrinsically Produced Reactive Oxygen Species Acting upon Specific Voltage-Gated NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Potential contributions of the intrinsic retinal oscillations recording using non-invasive electroretinogram to bioelectronics.Frontiers in cellular neuroscience · 2023Article
- Evaluating the Talbot-Plateau law.Frontiers in neuroscience · 2023Review
- Preventable risk factors for type 2 diabetes can be detected using noninvasive spontaneous electroretinogram signals.PloS one · 2023Article
- Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina.Frontiers in ophthalmology · 2023Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Neuronal discharge is driven by either synaptic input or cell-autonomous intrinsic pacemaker activity. It is commonly assumed that the resting spike activity of retinal ganglion cells (RGCs), the output cells of the retina, is driven synaptically, because retinal photoreceptors and second-order cells tonically release neurotransmitter. Here we show that ON and OFF RGCs generate maintained activity through different mechanisms: ON cells depend on tonic excitatory input to drive resting activity, whereas OFF cells continue to fire in the absence of synaptic input. In addition to spontaneous activity, OFF cells exhibit other properties of pacemaker neurons, including subthreshold oscillations, burst firing, and rebound excitation. Thus, variable weighting of synaptic mechanisms and intrinsic properties underlies differences in the generation of maintained activity in these parallel retinal pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.