ArticleJournal of clinical microbiology2007
Rapid detection directly from patient serum samples of human cytomegalovirus UL97 mutations conferring ganciclovir resistance.
Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Valganciclovir for the prevention of complications of late cytomegalovirus infection after allogeneic hematopoietic cell transplantation: a randomized trial.Annals of internal medicine · 2015Trial
- Ganciclovir Resistance-Linked Mutations in the HCMVDiagnostics (Basel, Switzerland) · 2025Article
- Clinical and genotypic CMV drug resistance in HSCT recipients: a single center epidemiological and clinical data.Bone marrow transplantation · 2019Article
- Risk Factors and Outcomes of Ganciclovir-Resistant Cytomegalovirus Infection in Solid Organ Transplant Recipients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- How I treat resistant cytomegalovirus infection in hematopoietic cell transplantation recipients.Blood · 2016Article
- Successful ganciclovir treatment of primary cytomegalovirus infection containing the UL97 mutation N510S in an intestinal graft recipient.Infection · 2013Article
- Rapid detection of human cytomegalovirus UL97 and UL54 mutations directly from patient samples.Journal of clinical microbiology · 2013Article
- Primary response against cytomegalovirus during antiviral prophylaxis with valganciclovir, in solid organ transplant recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2011Article
- Molecular analysis of varicella vaccines and varicella-zoster virus from vaccine-related skin lesions.Clinical and vaccine immunology : CVI · 2011Article
- Pyrosequencing allows the detection of emergent ganciclovir resistance mutations after HCMV infection.Medical microbiology and immunology · 2011Article
- Functional characterization of novel mutations in UL54 of ganciclovir resistant HCMV strain using structural analysis.Bioinformation · 2011Article
- Improved detection of mutated human cytomegalovirus UL97 by pyrosequencing.Antimicrobial agents and chemotherapy · 2010Article
- Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance.Antimicrobial agents and chemotherapy · 2010Article
- Variable viral clearance despite adequate ganciclovir plasma levels during valganciclovir treatment for cytomegalovirus disease in D+/R- transplant recipients.BMC infectious diseases · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ganciclovir-resistant cytomegalovirus can cause disease and death in transplant recipients. We describe here a rapid PCR- and sequencing-based assay for ganciclovir resistance that can be performed in 1 to 2 working days directly from patient specimens, without the need for amplification of the virus by cell culture. An evaluation of 120 sequential samples submitted for clinical testing revealed a variety of silent and amino acid mutations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.