ArticleNucleic acids research2007
A new connection of mRNP biogenesis and export with transcription-coupled repair.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Histone variant H2A.Z is needed for efficient transcription-coupled NER and genome integrity in UV challenged yeast cells.PLoS genetics · 2024Article
- DEAD-Box RNA Helicases and Genome Stability.Genes · 2021Review
- Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes.Nucleic acids research · 2018Article
- Transcription-coupled repair: an update.Archives of toxicology · 2016Review
- Nucleotide excision repair in humans.DNA repair · 2015Review
- Transcription Blockage Leads to New Beginnings.Biomolecules · 2015Review
- Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae.PLoS genetics · 2014Article
- Npl3, a new link between RNA-binding proteins and the maintenance of genome integrity.Cell cycle (Georgetown, Tex.) · 2014Article
- Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II.PLoS genetics · 2013Article
- Review
- A genome-wide screen identifies yeast genes required for tolerance to technical toxaphene, an organochlorinated pesticide mixture.PloS one · 2013Article
- An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.RNA (New York, N.Y.) · 2011Article
- Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance.BMC systems biology · 2011Article
- The Prp19 complex is a novel transcription elongation factor required for TREX occupancy at transcribed genes.Genes & development · 2011Article
- The nuclear pore complex: bridging nuclear transport and gene regulation.Nature reviews. Molecular cell biology · 2010Review
- Abasic sites in the transcribed strand of yeast DNA are removed by transcription-coupled nucleotide excision repair.Molecular and cellular biology · 2010Article
- Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas.Cancer science · 2009Article
- Expression of bacterial Rho factor in yeast identifies new factors involved in the functional interplay between transcription and mRNP biogenesis.Molecular and cellular biology · 2009Article
- Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair.PLoS genetics · 2009Article
- A novel class of mRNA-containing cytoplasmic granules are produced in response to UV-irradiation.Molecular biology of the cell · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution of mRNP biogenesis and export in transcription-coupled repair (TCR). Interestingly, mutants of THO, a transcription complex involved in maintenance of genome integrity, mRNP biogenesis and export, were recently found to be deficient in nucleotide excision repair. In this study we show by molecular DNA repair analysis, that Sub2-Yra1 and Thp1-Sac3, two main mRNA export complexes, are required for efficient TCR in yeast. Careful analysis revealed that THO mutants are also specifically affected in TCR. Ribozyme-mediated mRNA self-cleavage between two hot spots for UV damage showed that efficient TCR does not depend on the nascent mRNA, neither in wild-type nor in mutant cells. Along with severe UV damage-dependent loss in processivity, RNAPII was found binding to chromatin upon UV irradiation in THO mutants, suggesting that RNAPII remains stalled at DNA lesions. Furthermore, Def1, a factor responsible for the degradation of stalled RNAPII, appears essential for the viability of THO mutants subjected to DNA damage. Our results indicate that RNAPII is not proficient for TCR in mRNP biogenesis and export mutants, opening new perspectives on our knowledge of TCR in eukaryotic cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.