ArticleDevelopmental and comparative immunology2008
Microarray analyses reveal distinct roles for Rel proteins in the Drosophila immune response.
Article in Developmental and comparative immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
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- Co-option of immune effectors by the hormonal signalling system triggering metamorphosis in Drosophila melanogaster.PLoS genetics · 2021Article
- The effect of Wolbachia on gene expression in Drosophila paulistorum and its implications for symbiont-induced host speciation.BMC genomics · 2019Article
- Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.Genome medicine · 2018Article
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- Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling.The EMBO journal · 2014Article
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- Francisella is sensitive to insect antimicrobial peptides.Journal of innate immunity · 2013Article
- Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila.Cell host & microbe · 2012Article
- Transcriptome analysis of Aedes aegypti transgenic mosquitoes with altered immunity.PLoS pathogens · 2011Article
- Wild-type Drosophila melanogaster as an alternative model system for investigating the pathogenicity of Candida albicans.Disease models & mechanisms · 2011Article
- Heterodimers of NF-kappaB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Caspar controls resistance to Plasmodium falciparum in diverse anopheline species.PLoS pathogens · 2009Article
- Dorsal interacting protein 3 potentiates activation by Drosophila Rel homology domain proteins.Developmental and comparative immunology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The NF-kappaB group of transcription factors play an important role in mediating immune responses in organisms as diverse as insects and mammals. The fruit fly Drosophila melanogaster express three closely related NF-kappaB-like transcription factors: Dorsal, Dif, and Relish. To study their roles in vivo, we used microarrays to determine the effect of null mutations in individual Rel transcription factors on larval immune gene expression. Of the 188 genes that were significantly up-regulated in wild-type larvae upon bacterial challenge, overlapping but distinct groups of genes were affected in the Rel mutants. We also ectopically expressed Dorsal or Dif and used cDNA microarrays to determine the genes that were up-regulated in the presence of these transcription factors. This expression was sufficient to drive expression of some immune genes, suggesting redundancy in the regulation of these genes. Combining this data, we also identified novel genes that may be specific targets of Dif.
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