ArticleBMC bioinformatics2007
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base.
Article in BMC bioinformatics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development?Frontiers in endocrinology · 2019Review
- Compression of structured high-throughput sequencing data.PloS one · 2013Article
- A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer.Methods in molecular biology (Clifton, N.J.) · 2013Article
- The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization.The Journal of biological chemistry · 2012Article
- A new approach for studying GPCR dimers: drug-induced inactivation and reactivation to reveal GPCR dimer function in vitro, in primary culture, and in vivo.Pharmacology & therapeutics · 2012Review
- Article
- Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes.Pharmacological reviews · 2010Review
- Oligomeric forms of G protein-coupled receptors (GPCRs).Trends in biochemical sciences · 2010Article
- GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.Bioinformatics (Oxford, England) · 2010Article
- Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?Life sciences · 2010Review
- Gene set enrichment meta-learning analysis: next- generation sequencing versus microarrays.BMC bioinformatics · 2010Article
- Progress in elucidating the structural and dynamic character of G Protein-Coupled Receptor oligomers for use in drug discovery.Current pharmaceutical design · 2009Review
- Transepithelial projections from basal cells are luminal sensors in pseudostratified epithelia.Cell · 2008Article
- Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors.Expert opinion on drug discovery · 2008Article
- A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization.British journal of pharmacology · 2008Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundG Protein-Coupled Receptors (GPCRs) are a large and diverse family of membrane proteins whose members participate in the regulation of most cellular and physiological processes and therefore represent key pharmacological targets. Although several bioinformatics resources support research on GPCRs, most of these have been designed based on the traditional assumption that monomeric GPCRs constitute the functional receptor unit. The increase in the frequency and number of reports about GPCR dimerization/oligomerization and the implication of oligomerization in receptor function makes necessary the ability to store and access information about GPCR dimers/oligomers electronically.
resultsWe present here the requirements and ontology (the information scheme to describe oligomers and associated concepts and their relationships) for an information system that can manage the elements of information needed to describe comprehensively the phenomena of both homo- and hetero-oligomerization of GPCRs. The comprehensive information management scheme that we plan to use for the development of an intuitive and user-friendly GPCR-Oligomerization Knowledge Base (GPCR-OKB) is the result of a community dialog involving experimental and computational colleagues working on GPCRs.
conclusionOur long term goal is to disseminate to the scientific community organized, curated, and detailed information about GPCR dimerization/oligomerization and its related structural context. This information will be reported as close to the data as possible so the user can make his own judgment on the conclusions drawn for a particular study. The requirements and ontology described here will facilitate the development of future information systems for GPCR oligomers that contain both computational and experimental information about GPCR oligomerization. This information is freely accessible at http://www.gpcr-okb.org.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.