ReviewKlinische Wochenschrift1991
Structure-function correlations in erythropoietin formation and oxygen sensing in the kidney.
Review in Klinische Wochenschrift, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Nobel Prize 2019 pays tribute to translational physiology on oxygen sensing.Pflugers Archiv : European journal of physiology · 2019Article
- Age-dependent impairment of the erythropoietin response to reduced central venous pressure in HFpEF patients.Physiological reports · 2019Article
- Endocrine functions of the renal interstitium.Pflugers Archiv : European journal of physiology · 2017Review
- Erythropoietin production by PDGFR-β(+) cells.Pflugers Archiv : European journal of physiology · 2016Article
- The effect of erythropoietin on normal and neoplastic cells.Biologics : targets & therapy · 2012Article
- The renal cortical interstitium: morphological and functional aspects.Histochemistry and cell biology · 2008Review
- Mechanism underlying early anaemia in children with familial juvenile nephronophthisis.Pediatric nephrology (Berlin, Germany) · 1996Article
- Morphology of interstitial cells in the healthy kidney.Anatomy and embryology · 1996Review
- Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo.Pflugers Archiv : European journal of physiology · 1996Article
- Influence of hypoxia on hepatic and renal endothelin gene expression.Pflugers Archiv : European journal of physiology · 1996Article
- Human erythropoietin response to hypocapnic hypoxia, normocapnic hypoxia, and hypocapnic normoxia.European journal of applied physiology and occupational physiology · 1996Article
- Distribution of ecto-5'-nucleotidase in the rat liver: effect of anaemia.Histochemistry · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kidney is the main site of erythropoietin (EPO) formation. Oxygen sensing in the kidney itself plays a major role in the control of EPO synthesis. By in situ hybridization it has been established that the EPO-producing cells are situated in the interstitium of the cortical labyrinth, but they have not been precisely identified. Morphological findings provide new insights into the location and mechanism of oxygen sensing in the kidney. In addition to causing an increase in the number of cells containing EPO messenger RNA, anemia provokes structural changes exclusively in the cortical labyrinth. Specifically, the fibroblasts become enlarged and show increased activity of 5'-nucleotidase, and the S1 segment of the proximal tubule shows similar alterations as in various models of hypoxia. Thus, structures that are situated in the close vicinity of the EPO-producing cells appear to be sensitive to decreased oxygen delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.