ArticleJournal of biosciences2007
Molecular chaperones: the modular evolution of cellular networks.
Article in Journal of biosciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Self-Organization and Information Processing: From Basic Enzymatic Activities to Complex Adaptive Cellular Behavior.Frontiers in genetics · 2021Review
- Chaperome Networks - Redundancy and Implications for Cancer Treatment.Advances in experimental medicine and biology · 2020Review
- Pervasive convergent evolution and extreme phenotypes define chaperone requirements of protein homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cellular stress responses to chronic heat shock and shell damage in temperate Mya truncata.Cell stress & chaperones · 2018Article
- Pyrosequencing and de novo assembly of Antarctic krill (Euphausia superba) transcriptome to study the adaptability of krill to climate-induced environmental changes.Molecular ecology resources · 2015Article
- Elements of the cellular metabolic structure.Frontiers in molecular biosciences · 2015Article
- SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.PloS one · 2015Article
- Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation.PLoS computational biology · 2011Article
- Article
- Triggers of the HSP70 stress response: environmental responses and laboratory manipulation in an Antarctic marine invertebrate (Nacella concinna).Cell stress & chaperones · 2009Article
- POLAR MAPPER: a computational tool for integrated visualization of protein interaction networks and mRNA expression data.Journal of the Royal Society, Interface · 2009Article
- Surviving the cold: molecular analyses of insect cryoprotective dehydration in the Arctic springtail Megaphorura arctica (Tullberg).BMC genomics · 2009Article
- Functional organization of the yeast proteome by a yeast interactome map.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Intrinsically disordered proteins display no preference for chaperone binding in vivo.PLoS computational biology · 2008Article
- Underlying principles of natural selection in network evolution: systems biology approach.Evolutionary bioinformatics online · 2007Article
- Heat shock genes - integrating cell survival and death.Journal of biosciences · 2007Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular chaperones play a prominent role in signaling and transcriptional regulatory networks of the cell. Recent advances uncovered that chaperones act as genetic buffers stabilizing the phenotype of various cells and organisms and may serve as potential regulators of evolvability. Chaperones have weak links, connect hubs, are in the overlaps of network modules and may uncouple these modules during stress,which gives an additional protection for the cell at the network-level. Moreover,after stress chaperones are essential to re-build inter-modular contacts by their low affinity sampling of the potential interaction partners in different modules. This opens the way to the chaperone-regulated modular evolution of cellular networks,and helps us to design novel therapeutic and anti-aging strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.