ArticlePLoS medicine2007
Transparent development of the WHO rapid advice guidelines.
Article in PLoS medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 8 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Clinical practice guidelines for acute kidney injury: a systematic review of the methodological quality.Frontiers in medicine · 2025Pooled it
- Evidence-based clinical practice guidelines for the management of acute ankle injuries according to: a PRISMA systematic review and quality appraisal with AGREE II.BMC musculoskeletal disorders · 2024Pooled it
- Consideration of antimicrobial resistance and contextual factors in infectious disease guidelines: a systematic survey.BMJ open · 2021Pooled it
- Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version).Military Medical Research · 2020Guideline
- The GRADE Working Group clarifies the construct of certainty of evidence.Journal of clinical epidemiology · 2017Guideline
- Clinical practice guidelines for hypertension in China: a systematic review of the methodological quality.BMJ open · 2015Pooled it
- [Allergic rhinitis and its impact on asthma (ARIA update 2008). The Austrian perspective].Wiener medizinische Wochenschrift (1946) · 2009Guideline
- WHO Rapid Advice Guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virus.The Lancet. Infectious diseases · 2007Guideline
- Eight-step method to build the clinical content of an evidence-based care pathway: the case for COPD exacerbation.Trials · 2012Trial
- Evidence-to-Decision Frameworks: Enhancing the Quality and Rigour of Guidelines and Recommendations.Clinical and public health guidelines · 2026Article
- Methodology and experiences of rapid advice guideline development for children with COVID-19: responding to the COVID-19 outbreak quickly and efficiently.BMC medical research methodology · 2022Article
- Challenges in applying the GRADE approach in public health guidelines and systematic reviews: a concept article from the GRADE Public Health Group.Journal of clinical epidemiology · 2021Article
- Getting trustworthy guidelines into the hands of decision-makers and supporting their consideration of contextual factors for implementation globally: recommendation mapping of COVID-19 guidelines.Journal of clinical epidemiology · 2021Article
- Guidelines for the Management of Children and Adolescent with COVID-19: protocol for an update.Translational pediatrics · 2021Article
- Using GRADE in situations of emergencies and urgencies: certainty in evidence and recommendations matters during the COVID-19 pandemic, now more than ever and no matter what.Journal of clinical epidemiology · 2020Article
- A user guide to the American Society of Hematology clinical practice guidelines.Blood advances · 2020Article
- Rapid advice guidelines for management of children with COVID-19.Annals of translational medicine · 2020Review
- Coronavirus disease (COVID-19): a scoping review.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- GRADE guidelines: 18. How ROBINS-I and other tools to assess risk of bias in nonrandomized studies should be used to rate the certainty of a body of evidence.Journal of clinical epidemiology · 2019Article
- Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases.Clinical and translational allergy · 2019Review
Corrections and comments
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Authors and funding
19 authors at 10 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging health problems require rapid advice. We describe the development and pilot testing of a systematic, transparent approach used by the World Health Organization (WHO) to develop rapid advice guidelines in response to requests from member states confronted with uncertainty about the pharmacological management of avian influenza A (H5N1) virus infection. We first searched for systematic reviews of randomized trials of treatment and prevention of seasonal influenza and for non-trial evidence on H5N1 infection, including case reports and animal and in vitro studies. A panel of clinical experts, clinicians with experience in treating patients with H5N1, influenza researchers, and methodologists was convened for a two-day meeting. Panel members reviewed the evidence prior to the meeting and agreed on the process. It took one month to put together a team to prepare the evidence profiles (i.e., summaries of the evidence on important clinical and policy questions), and it took the team only five weeks to prepare and revise the evidence profiles and to prepare draft guidelines prior to the panel meeting. A draft manuscript for publication was prepared within 10 days following the panel meeting. Strengths of the process include its transparency and the short amount of time used to prepare these WHO guidelines. The process could be improved by shortening the time required to commission evidence profiles. Further development is needed to facilitate stakeholder involvement, and evaluate and ensure the guideline's usefulness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.