ReviewHuman genetics2007
Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease.
Review in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Association between the insulin-like growth factor 1 gene rs2195239 and rs2162679 polymorphisms and cancer risk: a meta-analysis.BMC medical genetics · 2019Pooled it
- Growth and associations between auxology, caregiving environment, and cognition in socially deprived Romanian children randomized to foster vs ongoing institutional care.Archives of pediatrics & adolescent medicine · 2010Trial
- Rare protein-coding variation and the genetic architecture of height in >1.4 million individuals.medRxiv : the preprint server for health sciences · 2026Article
- Association of tyrosine hydroxylase 01 (TH01) microsatellite and insulin gene (INS) variable number of tandem repeat (VNTR) with type 2 diabetes and fasting insulin secretion in Mexican population.Journal of endocrinological investigation · 2024Article
- miR-96-5p regulates cervical cancer cell resistance to cisplatin by inhibiting lncRNA TRIM52-AS1 and promoting IGF2BP2.The Kaohsiung journal of medical sciences · 2022Article
- Genomic Diversity Profiling and Breed-Specific Evolutionary Signatures of Selection in Arunachali Yak.Genes · 2022Article
- Microfluidic Quantitative PCR Detection of 12 Transgenes from Horse Plasma for Gene Doping Control.Genes · 2020Article
- Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice.PloS one · 2020Article
- Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways.Cells · 2019Review
- Perturbations to the IGF1 growth pathway and adult energy homeostasis following disruption of mouse chromosome 12 imprinting.Acta physiologica (Oxford, England) · 2014Article
- Article
- Generating new neurons to circumvent your fears: the role of IGF signaling.Cellular and molecular life sciences : CMLS · 2014Review
- Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth.Molecular biology of the cell · 2012Article
- Prenatal modulation of breast density and breast stem cells by insulin-like growth factor-1.American journal of stem cells · 2012Article
- Genome-wide DNA methylation and gene expression analyses of monozygotic twins discordant for intelligence levels.PloS one · 2012Article
- IV. Growth Failure in Institutionalized Children.Monographs of the Society for Research in Child Development · 2011Article
- Age relationships of postmortem observations in Portuguese Water Dogs.Age (Dordrecht, Netherlands) · 2011Article
- Prospective study of insulin-like growth factor-I, insulin-like growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease.International journal of molecular epidemiology and genetics · 2011Article
- A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories.The EMBO journal · 2011Article
- Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The human growth hormone gene (GH1) and the insulin-like growth factor 1 and 2 genes (IGF1 and IGF2) encode the central elements of a key pathway influencing growth in humans. This "growth pathway" also includes transcription factors, agonists, antagonists, receptors, binding proteins, and endocrine factors that constitute an intrincate network of feedback loops. GH1 is evolutionarily coupled with other genes in linkage disequilibrium in 17q24.2, and the same applies to IGF2 in 11p15.5. In contrast, IGF1 in 12q22-24.1 is not in strong linkage disequilibrium with neighbouring genes. Knowledge of the functional architecture of these regions is important for the understanding of the combined evolution and function of GH1, IGF2 and IGF1 in relation to complex diseases. A number of mutations accounting for rare Mendelian disorders have been described in GH-IGF elements. The constellation of genes in this key pathway contains potential candidates in a number of complex diseases, including growth disorders, metabolic syndrome, diabetes (notably IGF2BP2) cardiovascular disease, and central nervous system diseases, and in longevity, aging and cancer. We review these genes and their associations with disease phenotypes, with special attention to metabolic risk traits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.