ArticleInternational journal of legal medicine2007
First successful assay of Y-SNP typing by SNaPshot minisequencing on ancient DNA.
Article in International journal of legal medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 56 citations in OpenAlex.
- Ancient DNA analysis of elite nomadic warrior from Chinge-Tey I funerary commemorative complex in the "Valley of the Kings", Tuva.BMC genomics · 2025Article
- Forensic DNA phenotyping: a review on SNP panels, genotyping techniques, and prediction models.Forensic sciences research · 2025Review
- Paternal genetic landscape of contemporary Thai populations in the borderland provinces of Thailand and Myanmar.Scientific reports · 2025Article
- Effective resolution of the Y chromosome sublineages of the Iberian haplogroup R1b-DF27 with forensic purposes.International journal of legal medicine · 2019Article
- Revising mtDNA haplotypes of the ancient Hungarian conquerors with next generation sequencing.PloS one · 2017Article
- Forensically relevant SNaPshotInternational journal of legal medicine · 2017Review
- Multiplex quantification of four DNA targets in one reaction with Bio-Rad droplet digital PCR system for GMO detection.Scientific reports · 2016Article
- AmericaPlex26: a SNaPshot multiplex system for genotyping the main human mitochondrial founder lineages of the Americas.PloS one · 2014Article
- Method: a single nucleotide polymorphism genotyping method for Wheat streak mosaic virus.Investigative genetics · 2012Article
- Accurate determination of phenotypic information from historic thoroughbred horses by single base extension.PloS one · 2010Article
- Ancient DNA from European early neolithic farmers reveals their near eastern affinities.PLoS biology · 2010Article
- Identification and genotyping of Mycobacterium tuberculosis complex species by use of a SNaPshot Minisequencing-based assay.Journal of clinical microbiology · 2010Article
- Human evolution in Siberia: from frozen bodies to ancient DNA.BMC evolutionary biology · 2010Article
- Ancient DNA provides new insights into the history of south Siberian Kurgan people.Human genetics · 2009Article
- Pigment phenotype and biogeographical ancestry from ancient skeletal remains: inferences from multiplexed autosomal SNP analysis.International journal of legal medicine · 2009Article
- Subtyping of Y-chromosomal haplogroup E-M78 (E1b1b1a) by SNP assay and its forensic application.International journal of legal medicine · 2009Article
- Detection of the A189G mtDNA heteroplasmic mutation in relation to age in modern and ancient bones.International journal of legal medicine · 2009Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, a set of 13 Y-chromosomal single nucleotide polymorphisms (Y-SNPs) selected for the identification of the most frequent Asian Y-haplogroups was included in an allele-specific primer extension assay. Single nucleotide polymorphism (SNP) genotyping was accomplished by co-amplification of these 13 DNA fragments within 2 multiplex PCRs followed by detection with 1 minisequencing reaction using the SNaPshottrade mark Multiplex kit and analysis of extension products by capillary electrophoresis. First developed on modern samples, the assay was optimized for the analysis of 11 ancient DNA (aDNA) samples from the Krasnoyarsk region (southern Siberia) that were dated from 5,500-1,800 years before present (YBP). SNP typing was successful for most of them, which were all assigned to Y-haplogroup R1a1 except one. These results show that SNPs are well-suited for the analysis of aged and degraded DNA samples. Moreover, we found that the SNaPshot minisequencing methodology is a convenient, robust, and efficient method for SNP typing. To our knowledge, this study reports the first successful investigation of Y-SNPs on aDNA samples. The potential use of Y-SNPs in both evolutionary and forensic fields is also discussed.
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