ArticleNeoplasia (New York, N.Y.)2007
Molecular concepts analysis links tumors, pathways, mechanisms, and drugs.
Article in Neoplasia (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A pharmacogenomic method for individualized prediction of drug sensitivity.Molecular systems biology · 2011Pooled it
- Pooled it
- PanomiR: a systems biology framework for analysis of multi-pathway targeting by miRNAs.Briefings in bioinformatics · 2023Article
- 14-3-3 and Smad2/3 are crucial mediators of atypical-PKCs: Implications for neuroblastoma progression.Frontiers in oncology · 2023Article
- Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion.Cell adhesion & migration · 2021Article
- Weighted gene co-expression network analysis reveals modules and hub genes associated with the development of breast cancer.Medicine · 2019Observational
- The CXCR4-LASP1-eIF4F Axis Promotes Translation of Oncogenic Proteins in Triple-Negative Breast Cancer Cells.Frontiers in oncology · 2019Article
- The Pathway Coexpression Network: Revealing pathway relationships.PLoS computational biology · 2018Article
- CRTC2 promotes non-small cell lung cancer A549 migration and invasion in vitro.Thoracic cancer · 2018Article
- Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- ConceptMetab: exploring relationships among metabolite sets to identify links among biomedical concepts.Bioinformatics (Oxford, England) · 2016Article
- Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility.Molecular systems biology · 2016Article
- Mechanistic Support for Combined MET and AR Blockade in Castration-Resistant Prostate Cancer.Neoplasia (New York, N.Y.) · 2016Article
- ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms.Cancer research · 2015Article
- Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility.BMC medical genomics · 2015Article
- Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas.BMC medical genomics · 2015Article
- The CREB Coactivator CRTC2 Is a Lymphoma Tumor Suppressor that Preserves Genome Integrity through Transcription of DNA Mismatch Repair Genes.Cell reports · 2015Article
- Interaction of the Androgen Receptor, ETV1, and PTEN Pathways in Mouse Prostate Varies with Pathological Stage and Predicts Cancer Progression.Hormones & cancer · 2015Article
- Genome-Wide Expression of MicroRNAs Is Regulated by DNA Methylation in Hepatocarcinogenesis.Gastroenterology research and practice · 2015Article
- Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Global molecular profiling of cancers has shown broad utility in delineating pathways and processes underlying disease, in predicting prognosis and response to therapy, and in suggesting novel treatments. To gain further insights from such data, we have integrated and analyzed a comprehensive collection of "molecular concepts" representing > 2500 cancer-related gene expression signatures from Oncomine and manual curation of the literature, drug treatment signatures from the Connectivity Map, target gene sets from genome-scale regulatory motif analyses, and reference gene sets from several gene and protein annotation databases. We computed pairwise association analysis on all 13,364 molecular concepts and identified > 290,000 significant associations, generating hypotheses that link cancer types and subtypes, pathways, mechanisms, and drugs. To navigate a network of associations, we developed an analysis platform, the Molecular Concepts Map. We demonstrate the utility of the approach by highlighting molecular concepts analyses of Myc pathway activation, breast cancer relapse, and retinoic acid treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.