ArticlePloS one2007
Insulin-like growth factor 1 (IGF-1) mediates the effects of enriched environment (EE) on visual cortical development.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed, 119 citations in OpenAlex.
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- Rearing in a Shelved Environment Chronically Modifies Offspring Behaviour and Physiology.The European journal of neuroscience · 2025Article
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- Anesthetic effects on electrophysiological responses across the visual pathway.Scientific reports · 2024Article
- Enriched environment exposure during development positively impacts the structure and function of the visual cortex in mice.Scientific reports · 2023Article
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- Physical Exercise Modulates Brain Physiology Through a Network of Long- and Short-Range Cellular Interactions.Frontiers in molecular neuroscience · 2021Review
- Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex.Frontiers in cellular neuroscience · 2021Article
- Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats.International journal of molecular sciences · 2020Article
- The developmental support hypothesis: adaptive plasticity in neural development in response to cues of social support.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Environmental Enrichment Rescues Visually-Mediated Behavior in Ten-m3 Knockout Mice During an Early Critical Period.Frontiers in behavioral neuroscience · 2020Article
- Transcriptomic Landscape of von Economo Neurons in Human Anterior Cingulate Cortex Revealed by Microdissected-Cell RNA Sequencing.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Environmental Enrichment From Birth Impacts Parvalbumin Expressing Cells and Wisteria Floribunda Agglutinin Labelled Peri-Neuronal Nets Within the Developing Murine Striatum.Frontiers in neuroanatomy · 2019Article
- Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer's disease.Translational neurodegeneration · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enriched environment (EE) has been recently shown to affect visual cortex development and plasticity, and to prevent dark rearing effects. The factors mediating EE effects on visual cortical development and plasticity are still unclear. We have investigated whether IGF-1 is involved in mediating EE effects on the developing visual cortex. We show that EE increases the number of IGF-1 positive neurons in the visual cortex at P18. Increasing IGF-1 in the visual cortex of non-EE rats by means of osmotic minipumps implanted at P18 mimics EE effects, accelerating visual acuity development, assessed with Visual Evoked Potentials (VEPs). Blocking IGF-1 action in the visual cortex of EE rats by means of the IGF-1 receptor antagonist JB1 from P18 completely blocks EE action on visual acuity development. These results show that IGF-1 is a key factor mediating EE effects on visual cortical development. We then show that IGF-1 affects GAD65 immunoreactivity in perisomatic innervation and the condensation of Chondroitin Sulphate Proteoglycans (CSPGs) in perineuronal nets (PNNs) in the visual cortex. This suggests that IGF-1 action in mediating EE effects could be exerted through the modulation of intracortical inhibitory circuitry and PNN development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.