ReviewAmerican journal of Alzheimer's disease and other dementias
The genetics of Alzheimer's disease.
Review in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Fear of health insurance loss among individuals at risk for Huntington disease.American journal of medical genetics. Part A · 2008Trial
- Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives.IBRO neuroscience reports · 2024Review
- Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO).Medicina (Kaunas, Lithuania) · 2020Article
- Is Alzheimer's Also a Stem Cell Disease? - The Zebrafish Perspective.Frontiers in cell and developmental biology · 2018Article
- Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease.Advances in nutrition (Bethesda, Md.) · 2016Review
- Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities.Oncotarget · 2016Article
- Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases?BioMed research international · 2014Review
- Small amphipathic molecules modulate secondary structure and amyloid fibril-forming kinetics of Alzheimer disease peptide Aβ(1-42).The Journal of biological chemistry · 2012Article
- Genetics of Alzheimer disease.Journal of geriatric psychiatry and neurology · 2010Review
- Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid.Cerebrospinal fluid research · 2010Article
- Schizophrenia, psychiatric genetics, and Darwinian psychiatry: an evolutionary framework.Schizophrenia bulletin · 2008Review
- Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases.Molecular medicine (Cambridge, Mass.)Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetics of Alzheimer's disease is produced by 3 essentially interactive gene groups: (1) APP and presenilin 1 and 2; (2) APOE E2, E3, and E4; (3) genes on chromosomes 9, 10, 12, etc. If any gene in (1) mutates, beta amyloid (Abeta) increases sharply beyond what the genes of (3) can remove, with early-onset Alzheimer's disease the result. With retention of Abeta by E4 in (2), Alzheimer's disease might result even though (1) and (3) are normal. If any gene in (3) mutates, the level of Abeta will rise, but because many genes are involved in Abeta removal, late-onset Alzheimer's disease would be detected only eventually.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.