ArticleBritish journal of pharmacology2007
Chemogenomic approaches to drug discovery: similar receptors bind similar ligands.
Article in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- AΙ-Driven Drug Repurposing: Applications and Challenges.Medicines (Basel, Switzerland) · 2025Review
- Comprehensive detection and characterization of human druggable pockets through binding site descriptors.Nature communications · 2024Article
- SubMDTA: drug target affinity prediction based on substructure extraction and multi-scale features.BMC bioinformatics · 2023Article
- Repurposing miconazole and tamoxifen for the treatment of Mycobacterium abscessus complex infections through in silico chemogenomics approach.World journal of microbiology & biotechnology · 2023Article
- Deep Learning-Based Modeling of Drug-Target Interaction Prediction Incorporating Binding Site Information of Proteins.Interdisciplinary sciences, computational life sciences · 2023Article
- AlphaFold, allosteric, and orthosteric drug discovery: Ways forward.Drug discovery today · 2023Review
- In-silico target prediction by ensemble chemogenomic model based on multi-scale information of chemical structures and protein sequences.Journal of cheminformatics · 2023Article
- Improving Compound Activity Classification via Deep Transfer and Representation Learning.ACS omega · 2022Article
- Dihydroquinoline derivative as a potential anticancer agent: synthesis, crystal structure, and molecular modeling studies.Molecular diversity · 2021Article
- Machine learning approaches and databases for prediction of drug-target interaction: a survey paper.Briefings in bioinformatics · 2021Review
- Virtual Screening of Human Class-A GPCRs Using Ligand Profiles Built on Multiple Ligand-Receptor Interactions.Journal of molecular biology · 2020Article
- Discovery of sulfone-resistant dihydropteroate synthase (DHPS) as a target enzyme for kaempferol, a natural flavanoid.Heliyon · 2020Article
- Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective.Journal of medicinal chemistry · 2019Review
- Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria.Future medicinal chemistry · 2019Article
- Repertoires of G protein-coupled receptors forProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery.Frontiers in pharmacology · 2019Review
- A Novel Approach for Drug-Target Interactions Prediction Based on Multimodal Deep Autoencoder.Frontiers in pharmacology · 2019Article
- Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology.Cell reports · 2018Article
- Orthologue chemical space and its influence on target prediction.Bioinformatics (Oxford, England) · 2018Article
- Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds.Memorias do Instituto Oswaldo Cruz · 2018Article
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Abstract
Within recent years, a paradigm shift from traditional receptor-specific studies to a cross-receptor view has taken place within pharmaceutical research to increase the efficiency of modern drug discovery. Receptors are no longer viewed as single entities but grouped into sets of related proteins or receptor families that are explored in a systematic manner. This interdisciplinary approach attempting to derive predictive links between the chemical structures of bioactive molecules and the receptors with which these molecules interact is referred to as chemogenomics. Insights from chemogenomics are used for the rational compilation of screening sets and for the rational design and synthesis of directed chemical libraries to accelerate drug discovery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.