ArticleBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2007
High-content flow cytometry and temporal data analysis for defining a cellular signature of graft-versus-host disease.
Article in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 82 citations in OpenAlex.
- Activated CD4 + T lymphocyte is a potential biomarker for acute graft-vs.-host disease after hematopoietic stem cell transplantation in children with transfusion-dependent β-thalassemia.Frontiers in pediatrics · 2022Article
- flowEMMi: an automated model-based clustering tool for microbial cytometric data.BMC bioinformatics · 2019Article
- Robust Bayesian inference via coarsening.Journal of the American Statistical Association · 2019Article
- Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1.Haematologica · 2017Article
- Identifying Mixtures of Mixtures Using Bayesian Estimation.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2017Article
- Single and multi-subject clustering of flow cytometry data for cell-type identification and anomaly detection.BMC medical genomics · 2016Article
- Data augmentation for models based on rejection sampling.Biometrika · 2016Article
- Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.Science translational medicine · 2015Article
- Critical assessment of automated flow cytometry data analysis techniques.Nature methods · 2013Article
- A computational framework to emulate the human perspective in flow cytometric data analysis.PloS one · 2012Article
- Rapid cell population identification in flow cytometry data.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2011Article
- Misty Mountain clustering: application to fast unsupervised flow cytometry gating.BMC bioinformatics · 2010Article
- Data reduction for spectral clustering to analyze high throughput flow cytometry data.BMC bioinformatics · 2010Article
- Combining Mixture Components for Clustering.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2010Article
- The curvHDR method for gating flow cytometry samples.BMC bioinformatics · 2010Article
- flowClust: a Bioconductor package for automated gating of flow cytometry data.BMC bioinformatics · 2009Article
- flowCore: a Bioconductor package for high throughput flow cytometry.BMC bioinformatics · 2009Article
- A survey of flow cytometry data analysis methods.Advances in bioinformatics · 2009Article
- Analysis of High-Throughput Flow Cytometry Data Using plateCore.Advances in bioinformatics · 2009Article
- A chromatic explosion: the development and future of multiparameter flow cytometry.Immunology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Acute graft-versus-host disease (GVHD) is diagnosed by clinical and histologic criteria that are often nonspecific and typically apparent only after the disease is well established. Because GvHD is mediated by donor T cells and other immune effector cells, we sought to determine whether changes within a wide array of peripheral blood lymphocyte populations could predict the development of GvHD. Peripheral blood samples from 31 patients undergoing allogeneic blood and marrow transplant were analyzed for the proportion of 121 different subpopulations defined by 4-color combinations of lymphocyte phenotypic and activation markers at progressive time points posttransplant. Samples were processed using a newly developed high content flow cytometry technique and subjected to a spline- and functional linear discriminant analysis (FLDA)-based temporal analysis technique. This strategy identified a consistent posttransplant increase in the proportion and extent of fluctuation of CD3+CD4+CD8beta+ cells in patients who developed GVHD compared to those that did not. Although larger prospective clinical studies will be necessary to validate these results, this study demonstrates that high-content flow cytometry coupled with temporal analysis is a powerful approach for developing new diagnostic tools, and may be useful for developing a sensitive and specific predictive test for GVHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.