Evidence map›Paper›PMID 17531460›Full record

ReviewThe Journal of nutritional biochemistry2007

Vitamin D and aging: old concepts and new insights.

Beate Lanske, M Shawkat Razzaque

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of nutritional biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Vitamin D Activation and Mineral Ion Regulation.Advances in experimental medicine and biology · 2026
    Article
  5. Review
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  17. Alterations to maternal cortical and trabecular bone in multiparous middle-aged mice.Journal of musculoskeletal & neuronal interactions · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Beate LanskeDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA. beate_lanske@hsdm.harvard.edu
M Shawkat Razzaque
Harvard University · US

Funding

Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin DR01DK073944 · NIDDK · HARVARD MEDICAL SCHOOL · PI MANNSTADT, BEATE · 2007 to 2010
$1.7M
NIDDK NIH HHS R01 DK073944
6 · The paper itself

Abstract

Aging is a complex biological process driven by a selective class of molecules and pathways that affect overall deterioration of physiological functions to increase the risk of age-related diseases. A role of vitamin D in mammalian aging is well documented. Since vitamin D has an essential role in bone formation and mineralization, its deficiency results in impaired bone mineralization, such as rickets in children, osteomalacia in adults and osteoporosis in the aged population. Vitamin D replacement therapy therefore is one of the most commonly prescribed treatments for the elderly. Recent studies using genetically altered mouse models, such as in Fgf-23(-/-) and klotho mutant mice, that exhibit altered mineral ion metabolism due to high vitamin D activities showed features of premature aging that include atherosclerosis, emphysema, osteopenia/osteoporosis, hypogonadism, soft tissue calcifications and generalized atrophy of organs; the pathologic effects of vitamin D in these mouse models are obvious, as diminution or genetic ablation of the vitamin D pathway ameliorated most of the above-mentioned phenotypes, by reversing mineral ion metabolism, and the resultant effect being prolonged survival of the mutant mice. These in vivo mouse studies, although subject to further molecular characterization, add new insights into the role of vitamin D in aging.

Indexed as

AgingAnimalsAvitaminosisBone DensityBone DevelopmentCalcitriolDisease Models, AnimalFibroblast Growth Factor-23HumansVitamin DVitamin D DeficiencyCalcitriolFGF23 protein, humanFgf23 protein, mouseFibroblast Growth Factor-23Vitamin D

Identifiers

PMID17531460
PMCPMC2776629
OpenAlexW1995947878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.