ArticleCell proliferation2007
The influence of 3,3',5-triiodo-L-thyronine on human haematopoiesis.
Article in Cell proliferation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Graves disease complicated by agranulocytosis and thrombocytopenia in a 12-year-old girl.JCEM case reports · 2026Article
- The association between maternal FT3/FT4 ratio in early pregnancy and adverse neonatal outcomes: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Article
- Association between radioactive iodine uptake and neutropenia in untreated Graves' disease.Endocrine connections · 2023Article
- Can neutrophil/lymphocyte ratio be used as an indicator of inflammation in patients with hyperthyroidism?Journal of medical biochemistry · 2020Article
- The Impact of Growth Hormone Therapy on the Apoptosis Assessment in CD34+ Hematopoietic Cells from Children with Growth Hormone Deficiency.International journal of molecular sciences · 2017Article
- Observational
- The Role of the Multiple Hormonal Dysregulation in the Onset of "Anemia of Aging": Focus on Testosterone, IGF-1, and Thyroid Hormones.International journal of endocrinology · 2015Review
- Thryroid hormones and hematological indices levels in thyroid disorders patients at moi teaching and referral hospital, Western kenya.ISRN endocrinology · 2013Article
- THRB genetic polymorphisms can predict severe myelotoxicity after definitive chemoradiotherapy in patients with esophageal squamous cell carcinoma.International journal of medical sciences · 2012Article
- Minireview: Nuclear receptors, hematopoiesis, and stem cells.Molecular endocrinology (Baltimore, Md.) · 2010Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThyroid hormones mediate many physiological and developmental functions in humans. The role of the 3,3',5-triiodo-L-thyronine (T3) in normal human haematopoiesis at the cellular and molecular levels has not been determined. In this study, it was revealed that the human haematopoietic system might be directly depended on T3 influence. MATERIALS AND
methodsWe detected the TRalpha1 and TRbeta1 gene expression at the mRNA level in human cord blood, peripheral blood and bone marrow CD34(+)-enriched progenitor cells, using the RT-PCR method. Furthermore, we performed Western blotting to prove TRalpha1 and TRbeta1 expression occurs at the protein level in human cord blood, peripheral blood and bone marrow CD34(+) cells. In addition, the examined populations of cells were exposed in serum-free conditions to increasing doses of T3 and were subsequently investigated for clonogenic growth of granulocyte-macrophage colony-forming unit and erythrocyte burst-forming unit in methylcellulose cultures, and for the level of apoptosis, by employing annexin V staining and the terminal deoxynucleotidyltransferase-mediated dUTP nick-end labelling method. We investigated expression levels of apoptosis-related Bax and antiapoptotic Bcl-2 and Bcl-x(L) genes in the examined cells.
resultsWe found that exposure to higher and lower than normal concentration of thyroid hormone significantly influenced clonogenecity and induced apoptosis in human haematopoietic progenitor cells.
conclusionsThis study expands the understanding of the role of thyroid disorders in normal human haematopoiesis and indicates a direct influence of T3 on this process.
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