ArticlePLoS pathogens2007
Accumulation of pathological prion protein PrPSc in the skin of animals with experimental and natural scrapie.
Article in PLoS pathogens, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Diagnostic testing of chronic wasting disease in white-tailed deer (Odocoileus virginianus) by RT-QuIC using multiple tissues.PloS one · 2022Article
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- Classical scrapie in small ruminants is caused by at least four different prion strains.Veterinary research · 2021Article
- Neuropathology of Animal Prion Diseases.Biomolecules · 2021Review
- Assessing the aggregated probability of entry of a novel prion disease agent into the United Kingdom.Microbial risk analysis · 2020Article
- Detection of Pathognomonic Biomarker PrPBiomolecules · 2020Review
- Early preclinical detection of prions in the skin of prion-infected animals.Nature communications · 2019Article
- Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease.Science translational medicine · 2017Article
- Prions: Beyond a Single Protein.Clinical microbiology reviews · 2016Review
- Circulation of prions within dust on a scrapie affected farm.Veterinary research · 2015Article
- Objects in Contact with Classical Scrapie Sheep Act as a Reservoir for Scrapie Transmission.Frontiers in veterinary science · 2015Article
- Article
- Article
- Article
- The oral secretion of infectious scrapie prions occurs in preclinical sheep with a range of PRNP genotypes.Journal of virology · 2012Article
- PrPSc spreading patterns in the brain of sheep linked to different prion types.Veterinary research · 2011Article
- Pruritus in familial Creutzfeldt-Jakob disease: a common symptom associated with central nervous system pathology.Journal of neurology · 2011Article
- Is the presence of abnormal prion protein in the renal glomeruli of feline species presenting with FSE authentic?BMC veterinary research · 2010Article
- The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia.Acta neuropathologica · 2010Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prion infectivity and its molecular marker, the pathological prion protein PrP(Sc), accumulate in the central nervous system and often also in lymphoid tissue of animals or humans affected by transmissible spongiform encephalopathies. Recently, PrP(Sc) was found in tissues previously considered not to be invaded by prions (e.g., skeletal muscles). Here, we address the question of whether prions target the skin and show widespread PrP(Sc) deposition in this organ in hamsters perorally or parenterally challenged with scrapie. In hamsters fed with scrapie, PrP(Sc) was detected before the onset of symptoms, but the bulk of skin-associated PrP(Sc) accumulated in the clinical phase. PrP(Sc) was localized in nerve fibres within the skin but not in keratinocytes, and the deposition of PrP(Sc) in skin showed no dependence from the route of infection and lymphotropic dissemination. The data indicated a neurally mediated centrifugal spread of prions to the skin. Furthermore, in a follow-up study, we examined sheep naturally infected with scrapie and detected PrP(Sc) by Western blotting in skin samples from two out of five animals. Our findings point to the skin as a potential reservoir of prions, which should be further investigated in relation to disease transmission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.