ReviewJournal of muscle research and cell motility2007
Sarcomere dynamics during muscular contraction and their implications to muscle function.
Review in Journal of muscle research and cell motility, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Different Segments within Vertebrate Muscles Can Operate on Different Regions of Their Force-Length Relationships.Integrative and comparative biology · 2018Article
- Pelvic muscles' mechanical response to strains in the absence and presence of pregnancy-induced adaptations in a rat model.American journal of obstetrics and gynecology · 2018Article
- Kinetic coupling of phosphate release, force generation and rate-limiting steps in the cross-bridge cycle.Journal of muscle research and cell motility · 2017Review
- A multiscale chemo-electro-mechanical skeletal muscle model to analyze muscle contraction and force generation for different muscle fiber arrangements.Frontiers in physiology · 2014Article
- The interrelation between mechanical characteristics of contracting muscle, cross-bridge internal structure, and the mechanism of chemomechanical energy transduction.European biophysics journal : EBJ · 2012Article
- Mechanisms Of Residual Force Enhancement In Skeletal Muscle: Insights From Experiments And Mathematical Models.Biophysical reviews · 2011Article
- Gene transfer, expression, and sarcomeric incorporation of a headless myosin molecule in cardiac myocytes: evidence for a reserve in myofilament motor function.American journal of physiology. Heart and circulatory physiology · 2011Article
- Geometrical conditions indispensable for muscle contraction.International journal of molecular sciences · 2011Article
- Insights into human beta-cardiac myosin function from single molecule and single cell studies.Journal of cardiovascular translational research · 2009Review
- The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.Molecular biology of the cell · 2009Article
- Inter-sarcomere coordination in muscle revealed through individual sarcomere response to quick stretch.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Insights into the kinetics of Ca2+-regulated contraction and relaxation from myofibril studies.Pflugers Archiv : European journal of physiology · 2009Article
- The viscoelastic properties of passive eye muscle in primates. I: static forces and step responses.PloS one · 2009Article
- Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans.Nature · 2008Article
- Magnitude of sarcomere extension correlates with initial sarcomere length during lengthening of activated single fibers from soleus muscle of rats.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article attempts to identify the key aspects of sarcomere inhomogeneity and the dynamics of sarcomere length changes in muscle contraction experiments and focuses on understanding the mechanics of myofibrils or muscle fibres when viewed as independent units of biological motors (the half-sarcomeres) connected in series. Muscle force generation has been interpreted traditionally on the basis of the kinetics of crossbridge cycling, i.e. binding of myosin heads to actin and consecutive force generating conformational change of the head, under controlled conditions and assuming uniformity of sarcomere or half-sarcomere behaviour. However, several studies have shown that re-distribution of internal strain within myofibrils and muscle fibres may be a key player, particularly, during stretch or relaxation so that force kinetics parameters are strongly affected by sarcomere dynamics. Here, we aim to shed light on how force generation, crossbridge kinetics, and the complex sarcomere movements are to be linked and which mechanical concepts are necessary to develop a comprehensive contraction model of a myofibril.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.