Trial reportPediatric nephrology (Berlin, Germany)2007
Probiotics prophylaxis in children with persistent primary vesicoureteral reflux.
Trial report in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Non-antibiotic interventions for prevention of urinary tract infections in children: a systematic review and meta-analysis of randomized controlled trials.European journal of pediatrics · 2021Pooled it
- Long-term antibiotics for preventing recurrent urinary tract infection in children.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions for primary vesicoureteric reflux.The Cochrane database of systematic reviews · 2019Pooled it
- Probiotics for preventing urinary tract infection in people with neuropathic bladder.The Cochrane database of systematic reviews · 2017Pooled it
- Probiotics for preventing urinary tract infections in adults and children.The Cochrane database of systematic reviews · 2015Pooled it
- Efficacy of Probiotic Supplementation for Preventing Pediatric Urinary Tract Infections: A GRADE-Based Dose-Response Meta-Analysis.Health science reports · 2026Review
- Article
- Article
- Non-antibiotic Approaches to Preventing Pediatric UTIs: a Role for D-Mannose, Cranberry, and Probiotics?Current urology reports · 2022Review
- The female reproductive tract microbiotas, inflammation, and gynecological conditions.Frontiers in reproductive health · 2022Review
- Examination of Complementary Medicine for Treating Urinary Tract Infections Among Pregnant Women and Children.Frontiers in pharmacology · 2022Review
- Article
- Current status of long-term antibiotic prophylaxis for urinary tract infections in children: An antibiotic stewardship challenge.Kidney research and clinical practice · 2019Review
- Update on Associated Risk Factors, Diagnosis, and Management of Recurrent Urinary Tract Infections in Children.Journal of the Pediatric Infectious Diseases Society · 2019Review
- Prevention of Renal Scarring in Acute Pyelonephritis by Probiotic Therapy: an Experimental Study.Probiotics and antimicrobial proteins · 2019Article
- Nonantibiotic prevention and management of recurrent urinary tract infection.Nature reviews. Urology · 2018Review
- Antimicrobial Pharmacotherapy Management of Urinary Tract Infections in Pediatric Patients.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2018Review
- Probiotics prophylaxis in pyelonephritis infants with normal urinary tracts.World journal of pediatrics : WJP · 2016Article
- Efficacy of Fluoroquinolone/Probiotic Combination Therapy for Recurrent Urinary Tract Infection in Children: A Retrospective Analysis.Clinical therapeutics · 2015Article
- Probiotics prophylaxis in infants with primary vesicoureteral reflux.Pediatric nephrology (Berlin, Germany) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Probiotics, beneficial living microorganisms, have been proven to be effective in preventing gastrointestinal infections, but their effect in preventing urinary tract infection (UTI) is inconclusive. A prospective randomized controlled study was done to compare the preventive effect of probiotics with conventional antibiotics in children with persistent primary vesicoureteral reflux (VUR). One hundred twenty children who had had persistent primary VUR after antibiotic prophylaxis for 1 year were randomly allocated into a probiotics (Lactobacillus acidophilus 10(8) CFU/g 1 g b.i.d., n = 60) or an antibiotics (trimethoprim/sulfamethoxazole 2/10 mg/kg h.s., n = 60) prophylaxis group during the second year of follow-up. The incidence of recurrent UTI was 18.3% (11/60) in the probiotics group, which was not different from 21.6%(13/60) in the antibiotic group (P = 0.926). The causative organisms of recurrent UTI were not significantly different between the two groups (P = 0.938). Even after stratification by VUR grade, age, gender, phimosis, voiding dysfunction and renal scar, the incidence of recurrent UTI did not differ significantly between the two groups (P > 0.05). The development of new renal scar was not significantly different between the two groups (P > 0.05). In conclusion, probiotics prophylaxis was as effective as antibiotic prophylaxis in children with persistent primary VUR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.