ArticleJournal of neural transmission (Vienna, Austria : 1996)2007
Effect of spirulina maxima on the haloperidol induced tardive dyskinesia and oxidative stress in rats.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02837666 (Independent and Synergistic Effect of Spirulina Maxima With Exercise on General Fitness, Lipid Profile and Antioxidant Capacity in Overweight and Obese Subjects), which is not on this map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Independent and Synergistic Effect of Spirulina Maxima With Exercise on General Fitness, Lipid Profile and Antioxidant Capacity in Overweight and Obese Subjects
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Double-blind randomised controlled trial of the independent and synergistic effect ofBMJ open · 2017Trial
- Phytomedicines in preclinical and clinical research on antipsychotics-induced EPS/EPS-like behaviors: therapeutic effects and neurobiological mechanisms.Frontiers in psychiatry · 2026Review
- The Role of Astrocytes in the Molecular Pathophysiology of Schizophrenia: Between Neurodevelopment and Neurodegeneration.Biomolecules · 2025Review
- Cultivation of microalgae-bacteria consortium by waste gas-waste water to achieve COBiotechnology for biofuels and bioproducts · 2024Review
- Potential Protective Effects of Spirulina (International journal of molecular sciences · 2023Article
- The Janus face of antipsychotics in glial cells: Focus on glioprotection.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Beneficial Effects of Spirulina Consumption on Brain Health.Nutrients · 2022Review
- Assessment of Protective Effects of Carvacrol on Haloperidol-Induced Oxidative Stress and Genotoxicity in Human Peripheral Blood Lymphocytes.Journal of toxicology · 2022Article
- Protective Effect of Spirulina-Derived C-Phycocyanin against Ultraviolet B-Induced Damage in HaCaT Cells.Medicina (Kaunas, Lithuania) · 2021Article
- Effect of Spirulina platensis ingestion on the abnormal biochemical and oxidative stress parameters in the pancreas and liver of alloxan-induced diabetic rats.Pharmaceutical biology · 2017Article
- Spirulina maxima Extract Ameliorates Learning and Memory Impairments via Inhibiting GSK-3β Phosphorylation Induced by Intracerebroventricular Injection of Amyloid-β 1-42 in Mice.International journal of molecular sciences · 2017Article
- Antioxidant effects of Spirulina supplement against lead acetate-induced hepatic injury in rats.Journal of traditional and complementary medicine · 2016Article
- TOL19-001 reduces inflammation and MMP expression in monolayer cultures of tendon cells.BMC complementary and alternative medicine · 2015Article
- Oxidative stress and the antipsychotic-induced vacuous chewing movement model of tardive dyskinesia: evidence for antioxidant-based prevention strategies.Psychopharmacology · 2014Review
- Antioxidant effect of Spirulina (Arthrospira) maxima in a neurotoxic model caused by 6-OHDA in the rat striatum.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Neuroprotective effect of Spirulina in cerebral ischemia-reperfusion injury in rats.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae Spirulina.Cardiovascular therapeutics · 2010Review
- Protective effects of Spirulina maxima on hyperlipidemia and oxidative-stress induced by lead acetate in the liver and kidney.Lipids in health and disease · 2010Article
- Antioxidant effects of some drugs on immobilization stress combined with cold restraint stress.Molecules (Basel, Switzerland) · 2009Article
- Effect of alpha lipoic acid on the tardive dyskinesia and oxidative stress induced by haloperidol in rats.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haloperidol is a widely used neuroleptic drug for the treatment of acute and chronic psychosis. The use of haloperidol is limited by extrapyramidal movement disorders such as Parkinsonism, akathesia, dystonia, and tardive dyskinesia (TD). Treatment with haloperidol increases oxyradicals which are implicated in TD. Spirulina is widely used as nutritional supplement rich in proteins and antioxidants. The present study is proposed to study the effect of spirulina on haloperidol induced TD and oxidative stress by studying TD, various enzymatic and nonenzymatic antioxidants and lipid peroxidation. Haloperidol 1 mg/kg/i.p was used to induce vacuous chewing movements in rats. Spirulina maxima suspended in 1% between 80 at a dose of 45, 90 and 180 mg/kg were administered by gavage along with haloperidol from 21st day to 49th day of treatment. Spirulina supplementation at a dose of 180 mg/kg significantly improved enzymatic and nonenzymatic antioxidants and decreased the tardive dyskinesia induced by haloperidol. In conclusion, the results of present investigation suggest that spirulina decreases haloperidol induced oxidative stress and TD by many mechanisms as it is cocktail of antioxidants. On chronic use it may inhibit haloperidol induced reduced expression of DNA thereby increases the expression of enzymatic and nonenzymatic antioxidants and protects against oxidative stress induced neurodegeneration and TD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.