ArticleMolecular and cellular biology2007
A double-bromodomain protein, FSH-S, activates the homeotic gene ultrabithorax through a critical promoter-proximal region.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 50 citations in OpenAlex.
- Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer-factor-mediated zygotic genome activation.Molecular cell · 2025Article
- Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription.Nature communications · 2023Article
- Zebrafish ParalogsJournal of developmental biology · 2021Article
- Trajectory mapping of the earlyGenome research · 2021Article
- Kinome-Wide RNAi Screen Uncovers Role of Ballchen in Maintenance of Gene Activation by Trithorax Group inFrontiers in cell and developmental biology · 2021Article
- Global changes of H3K27me3 domains and Polycomb group protein distribution in the absence of recruiters Spps or Pho.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Polycomb and Trithorax Group Genes inGenetics · 2017Review
- Targeting Cancer Cells with BET Bromodomain Inhibitors.Cold Spring Harbor perspectives in medicine · 2017Review
- The GAGA factor regulatory network: Identification of GAGA factor associated proteins.PloS one · 2017Article
- The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins.International journal of molecular sciences · 2016Review
- Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.PLoS genetics · 2016Article
- Combgap contributes to recruitment of Polycomb group proteins in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- GAGA factor, a positive regulator of global gene expression, modulates transcriptional pausing and organization of upstream nucleosomes.Epigenetics & chromatin · 2016Article
- Two bromodomain proteins functionally interact to recapitulate an essential BRDT-like function in Drosophila spermatocytes.Open biology · 2015Article
- Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function.Genes & development · 2014Article
- Maintenance of cell fates through acetylated histone and the histone variant H2A.z in C. elegans.Worm · 2014Article
- Spatial expression of transcription factors in Drosophila embryonic organ development.Genome biology · 2013Article
- Distinct isoforms of the Drosophila Brd4 homologue are present at enhancers, promoters and insulator sites.Nucleic acids research · 2013Article
- Architectural and functional diversity of polycomb group response elements in Drosophila.Genetics · 2013Article
- Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.Genes & development · 2013Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
More than a dozen trithorax group (trxG) proteins are involved in activation of Drosophila HOX genes. How they act coordinately to integrate signals from distantly located enhancers is not fully understood. The female sterile (1) homeotic (fs(1)h) gene is one of the trxG genes that is most critical for Ultrabithorax (Ubx) activation. We show that one of the two double-bromodomain proteins encoded by fs(1)h acts as an essential factor in the Ubx proximal promoter. First, overexpression of the small isoform FSH-S, but not the larger one, can induce ectopic expression of HOX genes and cause body malformation. Second, FSH-S can stimulate Ubx promoter in cultured cells through a critical proximal region in a bromodomain-dependent manner. Third, purified FSH-S can bind specifically to a motif within this region that was previously known as the ZESTE site. The physiological relevance of FSH-S is ascertained using transgenic embryos containing a modified Ubx proximal promoter and chromatin immunoprecipitation. In addition, we show that FSH-S is involved in phosphorylation of itself and other regulatory factors. We suggest that FSH-S acts as a critical component of a regulatory circuitry mediating long-range effects of distant enhancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.