ArticleBiophysical journal2007
A kinetic model of single and clustered IP3 receptors in the absence of Ca2+ feedback.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 90 citations in OpenAlex.
- A structure-based computational model of IPBiophysical journal · 2024Article
- Modeling IPBiophysical journal · 2023Article
- An integrate-and-fire approach to CaBiophysical journal · 2023Article
- Upregulated CaCells · 2022Article
- Spatial-temporal patterning of CaSeminars in cell & developmental biology · 2019Review
- Insemination or phosphatidic acid induces an outwardly spiraling disk of elevated CaDevelopmental biology · 2019Article
- Synapse Formation Activates a Transcriptional Program for Persistent Enhancement in the Bi-directional Transport of Mitochondria.Cell reports · 2019Article
- All three IPScience signaling · 2018Article
- Data-driven modeling of mitochondrial dysfunction in Alzheimer's disease.Cell calcium · 2018Article
- IPCellular and molecular life sciences : CMLS · 2017Review
- Analyzing optical imaging of CaCell calcium · 2017Article
- Clusters of calcium release channels harness the Ising phase transition to confine their elementary intracellular signals.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Regulation of glomerulotubular balance: flow-activated proximal tubule function.Pflugers Archiv : European journal of physiology · 2017Review
- Comparison of CaCell calcium · 2017Article
- On the dynamical structure of calcium oscillations.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mode switching of Inositol 1,4,5-trisphosphate receptor channel shapes the Spatiotemporal scales of CaJournal of biological physics · 2016Article
- Emergence of ion channel modal gating from independent subunit kinetics.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Picomolar sensitivity to inositol trisphosphate in Xenopus oocytes.Cell calcium · 2015Article
- Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins.PLoS computational biology · 2015Article
- Shared functional defect in IP₃R-mediated calcium signaling in diverse monogenic autism syndromes.Translational psychiatry · 2015Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Ca2+ liberation through inositol 1,4,5-trisphosphate receptor (IP3R) channels generates complex patterns of spatiotemporal cellular Ca2+ signals owing to the biphasic modulation of channel gating by Ca2+ itself. These processes have been extensively studied in Xenopus oocytes, where imaging studies have revealed local Ca2+ signals ("puffs") arising from clusters of IP3R, and patch-clamp studies on isolated oocyte nuclei have yielded extensive data on IP3R gating kinetics. To bridge these two levels of experimental data, we developed an IP3R model and applied stochastic simulation and transition matrix theory to predict the behavior of individual and clustered IP3R channels. The channel model consists of four identical, independent subunits, each of which has an IP3-binding site together with one activating and one inactivating Ca2+-binding site. The channel opens when at least three subunits undergo a conformational change to an "active" state after binding IP3 and Ca2+. The model successfully reproduces patch-clamp data; including the dependence of open probability, mean open duration, and mean closed duration on [IP3] and [Ca2+]. Notably, the biexponential distribution of open-time duration and the dependence of mean open time on [Ca2+] are explained by populations of openings involving either three or four active subunits. As a first step toward applying the single IP3R model to describe cellular responses, we then simulated measurements of puff latency after step increases of [IP3]. Assuming that stochastic opening of a single IP3R at basal cytosolic [Ca2+] and any given [IP3] has a high probability of rapidly triggering neighboring channels by calcium-induced calcium release to evoke a puff, optimal correspondence with experimental data of puff latencies after photorelease of IP3 was obtained when the cluster contained a total of 40-70 IP3Rs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.