ArticleNucleic acids research2007
GeneTrail--advanced gene set enrichment analysis.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers.
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Who cites it
195 citing papers in PubMed.
- miRNAs and sports: tracking training status and potentially confounding diagnoses.Journal of translational medicine · 2016Trial
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- Higher Expression of Ku80 and Ku70 Indicates Hotter Tumor Immune Microenvironment in Hepatocellular Carcinoma and Better CTL-Centered Immunotherapy.Journal of inflammation research · 2024Article
- Evaluation of large language models for discovery of gene set function.Research square · 2023Article
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- PathIN: an integrated tool for the visualization of pathway interaction networks.Computational and structural biotechnology journal · 2023Article
- PRO-Simat: Protein network simulation and design tool.Computational and structural biotechnology journal · 2023Article
- Nine quick tips for pathway enrichment analysis.PLoS computational biology · 2022Article
- Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis.Cell host & microbe · 2022Article
- The impact of the genetic background in a patient with papillary thyroid cancer and familial adenomatous polyposis.Archives of endocrinology and metabolism · 2022Article
- Angiogenesis goes computational - The future way forward to discover new angiogenic targets?Computational and structural biotechnology journal · 2022Review
- Therapeutic Effects of Retinoic Acid in Lipopolysaccharide-Induced Cardiac Dysfunction: Network Pharmacology and Experimental Validation.Journal of inflammation research · 2022Article
- Expression of Cytokine-Coding GenesGenes · 2021Article
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- Toward a gold standard for benchmarking gene set enrichment analysis.Briefings in bioinformatics · 2021Article
- GeneTrail: A Framework for the Analysis of High-Throughput Profiles.Frontiers in molecular biosciences · 2021Article
135 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
We present a comprehensive and efficient gene set analysis tool, called 'GeneTrail' that offers a rich functionality and is easy to use. Our web-based application facilitates the statistical evaluation of high-throughput genomic or proteomic data sets with respect to enrichment of functional categories. GeneTrail covers a wide variety of biological categories and pathways, among others KEGG, TRANSPATH, TRANSFAC, and GO. Our web server provides two common statistical approaches, 'Over-Representation Analysis' (ORA) comparing a reference set of genes to a test set, and 'Gene Set Enrichment Analysis' (GSEA) scoring sorted lists of genes. Besides other newly developed features, GeneTrail's statistics module includes a novel dynamic-programming algorithm that improves the P-value computation of GSEA methods considerably. GeneTrail is freely accessible at http://genetrail.bioinf.uni-sb.de.
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