ArticleOncogene2007
Identification and characterization of a novel p42.3 gene as tumor-specific and mitosis phase-dependent expression in gastric cancer.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- SAPCD2 phosphorylation modulates astral microtubule stability to control spindle orientation.Communications biology · 2026Article
- Comprehensive Bioinformatics Analyses and Experimental Validation of the Cell Cycle Related Protein SAPCD2 as a New Biomarker and Potential Therapeutic Target in Pancreatic Cancer.Journal of inflammation research · 2025Article
- Prognostic value of RNA methylation-related genes in gastric adenocarcinoma based on bioinformatics.PeerJ · 2024Article
- MiR-486-5p specifically suppresses SAPCD2 expression, which attenuates the aggressive phenotypes of lung adenocarcinoma cells.Histology and histopathology · 2022Article
- SAPCD2 promotes neuroblastoma progression by altering the subcellular distribution of E2F7.Cell death & disease · 2022Article
- The Function and Regulation of SAPCD2 in Physiological and Oncogenic Processes.Journal of Cancer · 2022Review
- Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation.eLife · 2021Article
- Expression ofAnnals of translational medicine · 2020Article
- Overexpression of SAPCD2 correlates with proliferation and invasion of colorectal carcinoma cells.Cancer cell international · 2020Article
- Silencing SAPCD2 Represses Proliferation and Lung Metastasis of Fibrosarcoma by Activating Hippo Signaling Pathway.Frontiers in oncology · 2020Article
- Joint analysis of lncRNA mCancer cell international · 2020Article
- Long noncoding RNA PXN-AS1-L promotes the malignancy of nasopharyngeal carcinoma cells via upregulation of SAPCD2.Cancer medicine · 2019Article
- C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling.Oncogene · 2018Article
- Establishment of optimal regulatory network of colorectal cancer based on p42.3 protein.Saudi journal of biological sciences · 2017Article
- Depletion of p42.3 gene inhibits proliferation and invasion in melanoma cells.Journal of cancer research and clinical oncology · 2017Article
- Overexpression of p42.3 promotes cell proliferation, migration, and invasion in human gastric cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Helicobacter pylori and microRNAs: Relation with innate immunity and progression of preneoplastic conditions.World journal of clinical oncology · 2015Review
- Optimization and Corroboration of the Regulatory Pathway of p42.3 Protein in the Pathogenesis of Gastric Carcinoma.Computational and mathematical methods in medicine · 2015Article
- Differential expression of p42.3 in low- and high-grade gliomas.World journal of surgical oncology · 2014Article
- Maternal preconception body mass index and offspring cord blood DNA methylation: exploration of early life origins of disease.Environmental and molecular mutagenesis · 2014Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple genetic alterations are attributed to gastric cancer (GC); however, only a few critical genes have been identified so far. In this study, we isolated and characterized a novel gene p42.3, represented as tumor-specific and mitosis phase-dependent expression protein in GC cell line BGC823. Our data showed that the expression of p42.3 was cell cycle-dependent in GC cell lines. Moreover, p42.3 was specifically expressed in primary GC tissues but not in the matched normal mucosa of stomach, and this gene was expressed in diverse embryonic tissues. Furthermore, significant suppression of cell proliferation and tumorigenicity were detected and G(2)/M phase arrest was observed in cell line BGC823 depleted of p42.3 expression by RNAi technique, and we confirmed the expression changes of cyclin B1 and Chk2 following the silence of p42.3. Taken together, we cloned and characterized p42.3 gene that was specifically expressed in GC tumors but not in normal gastric mucosa, and the gene was associated with M-phase regulation. Moreover, p42.3 might be involved in cell proliferation and tumorigenesis; therefore, this gene might have potential applications in the diagnosis or treatment of GC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.