ArticleThe American journal of pathology2007
The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Laboratory safety of dupilumab in moderate-to-severe atopic dermatitis: results from three phase III trials (LIBERTY AD SOLO 1, LIBERTY AD SOLO 2, LIBERTY AD CHRONOS).The British journal of dermatology · 2020Pooled it
- The differential formation and composition of leukocyte-platelet aggregates induced by various cellular stimulants.Thrombosis research · 2024Article
- A multicellular vessel-on-a-chip model reveals context-dependent roles for platelets in inflammation and inflammatory hemostasis.Blood vessels, thrombosis & hemostasis · 2024Article
- Peripheral Blood Gene Expression Profile of Infants with Atopic Dermatitis.JID innovations : skin science from molecules to population health · 2023Article
- The blocking effect of the glycoprotein IIb/IIIa receptor in the mouse model of asthma.Clinical and molecular allergy : CMA · 2021Article
- Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2.Blood · 2020Article
- Platelets Aggregate With Neutrophils and Promote Skin Pathology in Psoriasis.Frontiers in immunology · 2019Article
- Base-modified UDP-sugars reduce cell surface levels of P-selectin glycoprotein 1 (PSGL-1) on IL-1β-stimulated human monocytes.Glycobiology · 2016Article
- The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation.Immunity · 2016Article
- Article
- Platelets: essential components of the immune system.Current trends in immunology · 2015Article
- Neutrophil Phagocytosis of Platelets in the Early Phase of 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced Dermatitis in Mice.Acta histochemica et cytochemica · 2014Article
- Platelets in inflammation: regulation of leukocyte activities and vascular repair.Frontiers in immunology · 2014Review
- Platelet-leukocyte interactions in cardiovascular disease and beyond.Arteriosclerosis, thrombosis, and vascular biology · 2010Review
- Platelet, not endothelial, P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivity.The American journal of pathology · 2010Article
- Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction.The American journal of pathology · 2010Article
- Innate immune cells induce hemorrhage in tumors during thrombocytopenia.The American journal of pathology · 2009Article
- Direct contact of platelets and their released products exert different effects on human dendritic cell maturation.BMC immunology · 2008Article
- Novel uses for anti-platelet agents as anti-inflammatory drugs.British journal of pharmacology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelets have been shown to be important in inflammation, but their role in chronic allergic dermatitis remains unclear. To investigate the role of platelets in a mouse model of chronic contact hypersensitivity induced by repeated elicitation, mice were sensitized and repeatedly elicited in ears with hapten, with or without platelet depletion, by administering antiplatelet antibody or busulfan. Ear thickness, leukocyte infiltration, serum IgE, and scratching behavior significantly decreased in thrombocytopenic mice. cDNA microarray of ear tissue showed reduced gene expression associated with Th2 lymphocytes. Flow cytometry showed increased P-selectin expression on platelets and an increased number of platelet-leukocyte aggregates in blood of repeatedly elicited mice, compared with sham-sensitized mice. In thrombocytopenic mice, inflammation was restored by platelet infusion, which was blocked by platelets from P-selectin-deficient mice or by pretreating platelets with anti-P-selectin antibody. Moreover, injection of activated platelet supernatant into ears led to increased leukocyte infiltration, which was blocked by pretreating platelets with antiplatelet compounds or neutralizing several chemokines in the platelet supernatant. These results suggest that platelets induce leukocyte recruitment into skin by forming platelet-leukocyte aggregates via P-selectin in blood and secreting chemokines at inflamed sites. Therefore, controlling platelet activity may be useful for treatment of chronic allergic dermatitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.