ArticleRNA (New York, N.Y.)2007
The C-terminal domain of RNA Pol II helps ensure that editing precedes splicing of the GluR-B transcript.
Article in RNA (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Exploring functional conservation in silico: a new machine learning approach to RNA-editing.Briefings in bioinformatics · 2024Article
- RNA Editing in Cancer Progression.Cancers · 2023Review
- RNA editing in nascent RNA affects pre-mRNA splicing.Genome research · 2018Article
- A to I editing in disease is not fake news.RNA biology · 2017Review
- ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins.Nucleic acids research · 2017Article
- Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma.The Journal of biological chemistry · 2017Article
- Adaptation of A-to-I RNA editing in Drosophila.PLoS genetics · 2017Article
- Adenosine to Inosine editing frequency controlled by splicing efficiency.Nucleic acids research · 2016Article
- Review
- The emerging role of RNA editing in plasticity.The Journal of experimental biology · 2015Review
- Mechanism of alternative splicing and its regulation.Biomedical reports · 2015Article
- Reovirus-mediated induction of ADAR1 (p150) minimally alters RNA editing patterns in discrete brain regions.Molecular and cellular neurosciences · 2014Article
- Coupling mRNA processing with transcription in time and space.Nature reviews. Genetics · 2014Review
- Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila.Nature structural & molecular biology · 2013Article
- Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR).RNA (New York, N.Y.) · 2013Article
- Modulation of dendritic AMPA receptor mRNA trafficking by RNA splicing and editing.Nucleic acids research · 2013Article
- Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing.Nucleic acids research · 2013Article
- Activity-regulated RNA editing in select neuronal subfields in hippocampus.Nucleic acids research · 2013Article
- A distant cis acting intronic element induces site-selective RNA editing.Nucleic acids research · 2012Article
- AMPA receptor regulation at the mRNA and protein level in rat primary cortical cultures.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The C-terminal domain (CTD) of the large subunit of RNA polymerase II (Pol II) influences many steps in the synthesis of an mRNA and helps control the final destiny of the mature transcript. ADAR2 edits RNA by converting adenosine to inosine within double-stranded or structured RNA. Site-selective A-to-I editing often occurs at sites near exon/intron borders, where it depends on intronic sequences for substrate recognition. It is therefore essential that editing precedes splicing. We have investigated whether there is coordination between ADAR2 editing and splicing of the GluR-B pre-mRNA. We show that the CTD is required for efficient editing at the R/G site one base upstream of a 5'-splice site. The results suggest that the CTD enhances editing at the R/G site by preventing premature splicing that would remove the intronic recognition sites for ADAR2. Editing at the GluR-B Q/R site, 24 bases upstream of the intron 11 5'-splice site, stimulates splicing at this intron. Furthermore, unlike previously studied introns, the CTD actually inhibits excision of intron 11, which includes the complementary recognition sequences for the Q/R editing site. In summary, these results show that the CTD and ADAR2 function together to enforce the order of events that allows editing to precede splicing, and they furthermore suggest a new role for the CTD as a coordinator of two interdependent pre-mRNA processing events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.