ArticleProceedings of the National Academy of Sciences of the United States of America2007
Photoperiod reverses the effects of estrogens on male aggression via genomic and nongenomic pathways.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 118 citations in OpenAlex.
- Testosterone rapidly increases neural reactivity to threat in healthy men: a novel two-step pharmacological challenge paradigm.Biological psychiatry · 2014Trial
- Timed melatonin administration increases territorial but not non-territorial aggression in female Siberian hamsters.Hormones and behavior · 2026Article
- Estrogen Control of Social Behaviors.Annual review of neuroscience · 2025Review
- Estrogen profiling in blood and brain: Effects of season and an aggressive interaction in a songbird.PloS one · 2025Article
- Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice.Nature communications · 2024Article
- Social isolation and aggression training lead to escalated aggression and hypothalamus-pituitary-gonad axis hyperfunction in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- An Aggressive Interaction Rapidly Increases Brain Androgens in a Male Songbird during the Non-breeding Season.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Sex and seasonal differences in neural steroid sensitivity predict territorial aggression in Siberian hamsters.Hormones and behavior · 2023Article
- Brain and circulating steroids in an electric fish: Relevance for non-breeding aggression.PloS one · 2023Article
- Seasonal regulation of behaviour: what role do hormone receptors play?Proceedings. Biological sciences · 2020Article
- A Teleost Fish Model to Understand Hormonal Mechanisms of Non-breeding Territorial Behavior.Frontiers in endocrinology · 2020Review
- Melatonin mediates seasonal transitions in aggressive behavior and circulating androgen profiles in male Siberian hamsters.Hormones and behavior · 2020Article
- Transcriptomic response to aquaculture intensification in Nile tilapia.Evolutionary applications · 2019Article
- CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety.Alcohol (Fayetteville, N.Y.) · 2018Review
- Rapid effects of 17β-estradiol on aggressive behavior in songbirds: Environmental and genetic influences.Hormones and behavior · 2018Review
- The impact of sex as a biological variable in the search for novel antidepressants.Frontiers in neuroendocrinology · 2018Review
- Sex differences in the brain: Implications for behavioral and biomedical research.Neuroscience and biobehavioral reviews · 2018Review
- Rapid actions of oestrogens and their receptors on memory acquisition and consolidation in females.Journal of neuroendocrinology · 2018Review
- Biological Clocks and Rhythms of Anger and Aggression.Frontiers in behavioral neuroscience · 2018Review
- Neural Androgen Synthesis and Aggression: Insights From a Seasonally Breeding Rodent.Frontiers in endocrinology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Despite recent discoveries of the specific contributions of genes to behavior, the molecular mechanisms mediating contributions of the environment are understudied. We demonstrate that the behavioral effects of estrogens on aggression are completely reversed by a discrete environmental signal, day length. Selective activation of either estrogen receptor alpha or beta decreases aggression in long days and increases aggression in short days. In the bed nucleus of the stria terminalis, one of several nuclei in a neural circuit that controls aggression, estrogen-dependent gene expression is increased in long days but not in short days, suggesting that estrogens decrease aggression by driving estrogen-dependent gene expression. Estradiol injections increased aggression within 15 min in short days but not in long days, suggesting that estrogens increase aggression in short days primarily via nongenomic pathways. These data demonstrate that the environment can dictate how hormones affect a complex behavior by altering the molecular pathways targeted by steroid receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.