ArticleThe Journal of physiology2007
Functional role of A-type potassium currents in rat presympathetic PVN neurones.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Multidimensional maturation of oxytocin neurons: A principal component analysis of postnatal development.Journal of neuroendocrinology · 2026Article
- Temperature modulates PVN pre-sympathetic neurones via transient receptor potential ion channels.Frontiers in pharmacology · 2023Article
- Angiotensin II inhibits the A-type KAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Article
- Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons.Scientific reports · 2021Article
- Article
- Kv4 channel expression and kinetics in GABAergic and non-GABAergic rNST neurons.Journal of neurophysiology · 2020Article
- Exacerbated effects of prorenin on hypothalamic magnocellular neuronal activity and vasopressin plasma levels during salt-sensitive hypertension.American journal of physiology. Heart and circulatory physiology · 2019Article
- Gain control with A-type potassium current: IA as a switch between divisive and subtractive inhibition.PLoS computational biology · 2018Article
- Hypothalamic Ion Channels in Hypertension.Current hypertension reports · 2018Review
- Ion Channels in the Paraventricular Hypothalamic Nucleus (PVN); Emerging Diversity and Functional Roles.Frontiers in physiology · 2018Review
- A-type KAmerican journal of physiology. Heart and circulatory physiology · 2017Article
- Tuning excitability of the hypothalamus via glutamate and potassium channel coupling.The Journal of physiology · 2017Article
- ERK1/2 MAPK signaling in hypothalamic paraventricular nucleus contributes to sympathetic excitation in rats with heart failure after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2016Article
- BDNF contributes to angiotensin II-mediated reductions in peak voltage-gated K+ current in cultured CATH.a cells.Physiological reports · 2015Article
- Nuclear localization and functional characteristics of voltage-gated potassium channel Kv1.3.The Journal of biological chemistry · 2015Article
- Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Central SDF-1/CXCL12 expression and its cardiovascular and sympathetic effects: the role of angiotensin II, TNF-α, and MAP kinase signaling.American journal of physiology. Heart and circulatory physiology · 2014Article
- Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation.The Journal of physiology · 2014Article
- H₂O₂ induces delayed hyperexcitability in nucleus tractus solitarii neurons.Neuroscience · 2014Article
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Authors and funding
2 authors.
Funding
Abstract
Despite the fact that paraventricular nucleus (PVN) neurones innervating the rostral ventrolateral medulla (RVLM) play important roles in the control of sympathetic function both in physiological and pathological conditions, the precise mechanisms controlling their activity are still incompletely understood. In the present study, we evaluated whether the transient outward potassium current I(A) is expressed in PVN-RVLM neurones, characterized its biophysical and pharmacological properties, and determined its role in shaping action potentials and firing discharge in these neurones. Patch-clamp recordings obtained from retrogradely labelled, PVN-RVLM neurones indicate that a 4-AP sensitive, TEA insensitive current, with biophysical properties consistent with I(A), is present in these neurones. Pharmacological blockade of I(A) depolarized resting V(m) and prolonged Na(+) action potential duration, by increasing its width and by slowing down its decay time course. Interestingly, blockade of I(A) either increased or decreased the firing activity of PVN-RVLM neurones, supporting the presence of subsets of PVN-RVLM neurones differentially modulated by I(A). In all cases, the effects of I(A) on firing activity were prevented by a broad spectrum Ca(2+) channel blocker. Immunohistochemical studies suggest that I(A) in PVN-RVLM neurons is mediated by Kv1.4 and/or Kv4.3 channel subunits. Overall, our results demonstrate the presence of I(A) in PVN-RVLM neurones, which actively modulates their action potential waveform and firing activity. These studies support I(A) as an important intrinsic mechanism controlling neuronal excitability in this central presympathetic neuronal population.
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