ArticleGenetics1991
Deletion of SNF1 affects the nutrient response of yeast and resembles mutations which activate the adenylate cyclase pathway.
Article in Genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 166 citations in OpenAlex.
- Sugar signals pedal the cell cycle!Frontiers in plant science · 2024Review
- Controlling circuitry underlies the growth optimization of Saccharomyces cerevisiae.Metabolic engineering · 2023Article
- A novel yeast hybrid modeling framework integrating Boolean and enzyme-constrained networks enables exploration of the interplay between signaling and metabolism.PLoS computational biology · 2021Article
- Transcriptional and post-translational activation of AMPKα by oxidative, heat, and cold stresses in the red flour beetle, Tribolium castaneum.Cell stress & chaperones · 2019Article
- Article
- Antagonism between salicylate and the cAMP signal controls yeast cell survival and growth recovery from quiescence.Microbial cell (Graz, Austria) · 2018Article
- Article
- Caloric Restriction Extends Yeast Chronological Life Span by Optimizing the Snf1 (AMPK) Signaling Pathway.Molecular and cellular biology · 2017Article
- Six plant extracts delay yeast chronological aging through different signaling pathways.Oncotarget · 2016Article
- Cross-Talk between Carbon Metabolism and the DNA Damage Response in S. cerevisiae.Cell reports · 2015Article
- Dysfunctional mitochondria modulate cAMP-PKA signaling and filamentous and invasive growth of Saccharomyces cerevisiae.Genetics · 2013Article
- Yeast glucose pathways converge on the transcriptional regulation of trehalose biosynthesis.BMC genomics · 2012Article
- Protein kinase A contributes to the negative control of Snf1 protein kinase in Saccharomyces cerevisiae.Eukaryotic cell · 2012Article
- Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe.Eukaryotic cell · 2012Article
- Roles of two protein phosphatases, Reg1-Glc7 and Sit4, and glycogen synthesis in regulation of SNF1 protein kinase.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The Hsp70 homolog Ssb is essential for glucose sensing via the SNF1 kinase network.Genes & development · 2009Article
- Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection.Molecular microbiology · 2008Article
- Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase.The Journal of biological chemistry · 2008Article
- SNF1/AMPK pathways in yeast.Frontiers in bioscience : a journal and virtual library · 2008Review
- Nutrient sensing in plant meristems.Plant molecular biology · 2006Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have isolated a snf1/ccr1 mutant of Saccharomyces cerevisiae which loses viability upon starvation and fails to accumulate glycogen in response to abrupt depletion of phosphate or glucose. A snf1 null mutant is sensitive to heat stress and starvation and fails to accumulate glycogen during growth in rich medium. The phenotypes of the snf1 mutants are those commonly associated with an overactivation of the adenylate cyclase pathway. Mutations in adenylate cyclase or RAS2 which decrease the level of cAMP in the cell moderate the snf1 phenotype. In contrast, a mutation in RAS2 (RAS2val19) which increases the level of cAMP or a mutation in the regulatory subunit (BCY1) of cAMP-dependent protein kinase which results in unregulated cAMP-dependent protein kinase activity accentuates the snf1 phenotype. However, the action of SNF1 in the stress response appears at least partly independent of cAMP-dependent protein kinase because a snf1 phenotype is observed in a strain that lacks all three of the genes that encode the catalytic subunits of cAMP-dependent protein kinase. SNF1 therefore acts at least in part through a cAMP-independent pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.