ArticleClinical drug investigation2004
Sodium and potassium disturbances in the elderly : prevalence and association with drug use.
Article in Clinical drug investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Active surveillance and risk prediction of piperacillin/tazobactam‑associated hypokalaemia: development and external validation of a clinical nomogram.International journal of clinical pharmacy · 2026Article
- A drug-based model to predict hyponatremia in outpatients of a geriatric clinic.European journal of clinical pharmacology · 2025Article
- Current and Future Burdens of Heat-Related Hyponatremia: A Nationwide Register-Based Study.The Journal of clinical endocrinology and metabolism · 2022Article
- Prevalence of hypokalemia in older persons: results from the PolSenior national survey.European geriatric medicine · 2021Article
- Normal range of serum potassium, prevalence of dyskalaemia and associated factors in Chinese older adults: a cross-sectional study.BMJ open · 2020Article
- Electrolyte outpatient clinic at a local hospital - experience from diagnostics, treatment and follow-up.BMC health services research · 2020Article
- Electrolyte imbalances in an unselected population in an emergency department: A retrospective cohort study.PloS one · 2019Article
- Drug-induced hyperkalemia.Drug safety · 2014Review
- Clinical features, outcome and cost of hyponatremia-associated admission and hospitalization in elderly and very elderly patients: a single-center experience in Turkey.International urology and nephrology · 2013Article
- The kidney and the elderly: why does the risk increase?International urology and nephrology · 2012Review
- Gender disparities in the pharmacological treatment of cardiovascular disease and diabetes mellitus in the very old: an epidemiological, cross-sectional survey.Drugs & aging · 2011Article
- [Diuretics-related complications in elderly patients].Wiener medizinische Wochenschrift (1946) · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the incidence of sodium and potassium disturbances in a population of the very old elderly, with respect to medication with potential effects on electrolyte levels. DESIGN AND
settingCross-sectional study of subjects aged >/=75 years, based on data from the Kungsholmen project, a population-based study of elderly in an urban area of Stockholm, Sweden. STUDY
participants1558 elderly individuals (1178 women and 380 men), mean age 81.4 years, providing information about drug use and serum electrolyte data.
main outcome measuresData on drug use was based on personal interviews. Hyponatraemia was defined as a serum sodium concentration <136 mmol/L, hypernatraemia as a serum sodium concentration >146 mmol/L, hypokalaemia as a serum potassium concentration <3.5 mmol/L and hyperkalaemia as a serum potassium concentration >5.0 mmol/L.
resultsHyponatraemia was found in 147 subjects (9.4% of the study population) and hypernatraemia in five individuals (0.3%). Hypokalaemia was found in 39 (2.5%) and hyperkalaemia in 43 (2.8%) of the subjects. The prevalence of hyponatraemia (p < 0.001), hypokalaemia (p < 0.05) and hyperkalaemia (p < 0.05) increased with age. Hyponatraemia was found more often in women than in men (p < 0.05). Hypernatraemia was more frequent in subjects who lived in institutions (p < 0.001). The occurrence of hyponatraemia was associated with the use of carbamazepine, laxatives (enema), diuretics and ACE-inhibitors; hypernatraemia was associated with osmotically active laxatives. Hypokalaemia was associated with thiazide-related and combination diuretics; and hyperkalaemia was associated with potassium-sparing diuretics, beta-blockers, cytostatic drugs and tricyclic antidepressants.
conclusionsThe present study demonstrated the association between electrolyte level disturbances and several types of drugs in a population of the very old elderly. Our results underline the importance of monitoring serum electrolyte levels in the elderly, not only in relation to the use of diuretics, but also several other drugs.
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