ArticleSurgical endoscopy2008
Peritoneal and systemic pH during pneumoperitoneum with CO2 and helium in a pig model.
Article in Surgical endoscopy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Laparoscopy versus laparotomy for FIGO stage I ovarian cancer.The Cochrane database of systematic reviews · 2016Pooled it
- Bowel obstruction after laparoscopic and open colon resection for cancer: results of 5 years of follow-up in a randomized trial.Surgical endoscopy · 2011Trial
- Premedication with acetazolamide: Is its use for postoperative pain and stress control after laparoscopic ovariectomy in dogs ruled out?Veterinary medicine and science · 2023Article
- Continuous pH monitoring using a sensor for the early detection of anastomotic leaks.Frontiers in medical technology · 2023Article
- Laparoscopic Surgery for Ovarian Neoplasms - What is Possible, What is Useful?Geburtshilfe und Frauenheilkunde · 2022Article
- Pneumoperitoneum in Veterinary Laparoscopy: A Review.Veterinary sciences · 2020Review
- Effects of Intraoperative Insufflation With Warmed, Humidified CO2 during Abdominal Surgery: A Review.Annals of coloproctology · 2018Article
- Acute elevation of intra-abdominal pressure contributes to extravascular shift of fluid and proteins in an experimental porcine model.BMC research notes · 2014Article
- Tumor necrosis factor expression is ameliorated after exposure to an acidic environment.The Journal of surgical research · 2012Article
- Cardiorespiratory and blood gas alterations during laparoscopic surgery for intra-uterine artificial insemination in dogs.The Canadian veterinary journal = La revue veterinaire canadienne · 2011Article
- Peritoneal changes due to laparoscopic surgery.Surgical endoscopy · 2011Review
- Sonographic findings following appendectomy for uncomplicated appendicitis in children.Pediatric radiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLocal peritoneal effects of laparoscopic gases might be important in peritoneal biology during and after laparoscopic surgery. The most commonly used gas, CO(2), is known to be well tolerated, but also causes changes in acid-base balance. Helium is an alternative gas for laparoscopy. Although safe, it is not widely used. In this study a method for monitoring peritoneal pH during laparoscopy was evaluated and peritoneal pH during CO(2) and helium pneumoperitoneum was studied as well as its systemic reflection in arterial pH.
methodsFor these experiments 20 pigs were used, with ten exposed to pneumoperitoneum with CO(2), and ten to helium. Peritoneal and sub-peritoneal pH were continuously measured before and during gas insufflation, during a 30-minute period with a pneumoperitoneum and during a 30-minute recovery period. Arterial blood-gases were collected immediately before gas insufflation, at its completion, at 30 minutes of pneumoperitoneum and after the recovery period.
resultsPeritoneal pH before gas insufflation was in all animals 7.4. An immediate local drop in pH (6.6) occurred in the peritoneum with CO(2) insufflation. During pneumoperitoneum pH declined further, stabilising at 6.4, but was restored after the recovery period (7.3). With helium, tissue pH increased slightly (7.5) during insufflation, followed by a continuous decrease during pneumoperitoneum and recovery, reaching 7.2. Systemic pH decreased significantly with CO(2) insufflation, and increased slightly during helium insufflation. Systemic pH showed co-variation with intra-peritoneal pH at the the end of insufflation and after 30 minutes of pneumoperitoneum.
conclusionsInsufflation of CO(2) into the peritoneal cavity seemed to result in an immediate decrease in peritoneal pH, a response that might influence biological events. This peritoneal effect also seems to influence systemic acid-base balance, probably due to trans-peritoneal absorption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.