ArticleSurgical endoscopy2007
Factors affecting the number of lymph nodes retrieved in colorectal cancer specimens.
Article in Surgical endoscopy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Defining a minimum nodal yield for neck dissection in mucosal head and neck squamous cell carcinoma, a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- Prognostic value of the nodal yield in head and neck squamous cell carcinoma: A systematic review.Head & neck · 2019Pooled it
- Comparison of different lymph node staging systems for predicting prognosis in patients with colon cancer who have undergone surgical resection.Oncology letters · 2022Article
- Article
- Evaluation of the prognostic relevance of the recommended minimum number of lymph nodes in colorectal cancer-a propensity score analysis.International journal of colorectal disease · 2021Article
- Lymph node retrieval after colorectal cancer surgery: a comparative study of the efficacy between the conventional manual method and a new fat dissolution method.Surgery today · 2020Article
- Trends in the Number of Lymph Nodes Evaluated Among Patients with Pancreatic Neuroendocrine Tumors in the United States: A Multi-Institutional and National Database Analysis.Annals of surgical oncology · 2020Article
- Young age increases the risk for lymph node metastasis in patients with early Colon Cancer.BMC cancer · 2019Article
- Impact of Age on Risk of Lymph Node Positivity in Patients with Colon Cancer.Journal of Cancer · 2019Article
- The Prognostic Impact of the Metastatic Lymph Nodes Ratio in Colorectal Cancer.Frontiers in oncology · 2018Article
- Lymph node yield in right colectomy for cancer: a comparison of open, laparoscopic and robotic approaches.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2017Article
- Population-based study to re-evaluate optimal lymph node yield in colonic cancer.The British journal of surgery · 2017Article
- Article
- Mesenteric root dissection with individualized ileo-colic vessel ligation versus mesenteric pedicle stapling.Surgical endoscopy · 2016Article
- Impact of age on the prognostic value of number of lymph nodes retrieved in patients with stage II colorectal cancer.International journal of colorectal disease · 2016Article
- Young Age Increases Risk of Lymph Node Positivity in Early-Stage Rectal Cancer.Journal of the National Cancer Institute · 2016Article
- Total number of lymph nodes in oncologic resections, is there more to be found?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Article
- Survival after laparoscopic and open surgery for colon cancer: a comparative, single-institution study.BMC surgery · 2015Article
- The impact of standard protocol implementation on the quality of colorectal cancer pathology reporting.World journal of surgery · 2015Article
- Colorectal cancer and lymph nodes: the obsession with the number 12.World journal of gastroenterology · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStaging of colorectal cancer is dependent on the number of lymph nodes in a surgical specimen that are positive for metastatic cancer. It is generally recommended that a minimum of 12 lymph nodes be examined to ensure adequate staging. It is unclear which factors specifically contribute to variation in the number of lymph nodes retrieved from surgical specimens. This study aims to understand the factors affecting the number of lymph nodes identified in surgical colorectal cancer specimens.
methodsA total of 264 retrospectively collected cases of colorectal cancer surgically treated at the University Health Network in Toronto from 2004 to 2006 were analyzed. We used univariate analyses of variance (ANOVA), and univariate and multivariable linear and logistic regression analyses to study variation in the lymph node number associated with a variety of explanatory variables.
resultsThe average number of lymph nodes retrieved per case was 18.1, with 70 (26.5%) cases containing fewer than 12. Variation in the lymph node number was greatest between different pathology assistants (p = or< 0.001). The mean number of nodes retrieved by different pathology assistants ranged from 12.6 to 29.7. On average, surgery for recurrent cancer removed 6.0 (95% CI 1.2 to 10.9, p = 0.02) fewer lymph nodes than for primary cancer. Each additional year of patient age was associated with retrieval of 0.1 (95% CI 0.04 to 0.2, p = 0.005) fewer nodes, and rectal cancer specimens had 2.7 (95% CI 0.04 to 5.4, p = 0.05) fewer lymph nodes than colon cancer specimens.
conclusionMost of the variation in the number of lymph nodes identified in surgical specimens from colorectal cancer operations was accounted for by differences between pathology assistants.
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