ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2007
Modified skin window technique for the extended characterisation of acute inflammation in humans.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Novel translational model of resolving inflammation triggered by UV-killed E. coli.The journal of pathology. Clinical research · 2016Article
- Dietary Fiber Intake is Associated with Increased Colonic Mucosal GPR43+ Polymorphonuclear Infiltration in Active Crohn's Disease.Nutrients · 2015Article
- A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- What is wrong with granulocytes in inflammatory bowel diseases?Digestive diseases (Basel, Switzerland) · 2013Review
- Modified skin-window technique in cynomolgus macaques (Macaca fasicularis) for assessing neutrophil extravasation.Journal of the American Association for Laboratory Animal Science : JAALAS · 2010Article
- Diminished macrophage apoptosis and reactive oxygen species generation after phorbol ester stimulation in Crohn's disease.PloS one · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo modify the skin window technique for extended analysis of acute inflammatory responses in humans, and demonstrate its applicability for investigating disease. SUBJECTS: 15 healthy subjects and 5 Crohn's patients. TREATMENT: Skin windows, created by dermal abrasion, were overlaid for various durations with filter papers saturated in saline, 100 ng/ml muramyl dipeptide (MDP) or 10 microg/ml interleukin-8 (IL-8).
methodsExuded leukocytes were analyzed by microscopy, immunoblot, DNA-bound transcription factor arrays and RT-PCR. Inflammatory mediators were quantified by ELISA.
resultsInfiltrating leukocytes were predominantly neutrophils. Numerous secreted mediators were detectable. MDP and IL-8 enhanced responses. Many signalling proteins were phosphorylated with differential patterns in Crohn's patients, notably PKC alpha/beta hyperphosphorylation (11.3 +/- 3.1 vs 1.2 +/- 0.9 units, P < 0.02). Activities of 44 transcription factors were detectable, and sufficient RNA isolated for expression analysis of over 400 genes.
conclusionsThe modifications enable broad characterisation of inflammatory responses and administration of exogenous immunomodulators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.