ArticleAnnals of surgery2007
Sentinel lymph node biopsy in colon cancer: a prospective multicenter trial.
Article in Annals of surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Near-infrared fluorescence imaging for sentinel lymph node identification in colon cancer: a prospective single-center study and systematic review with meta-analysis.Techniques in coloproctology · 2019Pooled it
- Is it time for one-step nucleic acid amplification (OSNA) in colorectal cancer? A systematic review and meta-analysis.Techniques in coloproctology · 2017Pooled it
- Dramatic innovations in modern surgical subspecialties.Canadian journal of surgery. Journal canadien de chirurgie · 2010Pooled it
- Sentinel Lymph Node Mapping with Isosulfan Blue or Indocyanine Green in Colon Cancer Shows Comparable Results and Identifies Patients with Decreased Survival: A Prospective Single-Center Trial.World journal of surgery · 2017Trial
- A multi-center study of using carbon nanoparticles to track lymph node metastasis in T1-2 colorectal cancer.Surgical endoscopy · 2014Trial
- Factors influencing the success of in vivo sentinel lymph node procedure in colon cancer patients: Swiss prospective, multicenter study sentinel lymph node procedure in colon cancer.World journal of surgery · 2013Trial
- Colorectal cancer lymph node staining by activated carbon nanoparticles suspension in vivo or methylene blue in vitro.World journal of gastroenterology · 2012Trial
- Ultrastaging of colon cancer by sentinel node biopsy using fluorescence navigation with indocyanine green.International journal of colorectal disease · 2012Trial
- One hundred consecutive cases of sentinel lymph node mapping in colon cancer-the results of prospective, single--centre feasibility study with implementation of immunohistochemical staining.International journal of colorectal disease · 2011Trial
- The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the Enroute⊕ Study.BMC surgery · 2011Trial
- [Sentinel lymph node mapping in colorectal and anal tumors from the beginning until now].Magyar onkologia · 2026Article
- Using contrast-enhancing software to improve sentinel lymph node detection with indocyanine green in colon cancer surgery.Techniques in coloproctology · 2026Article
- Mapping Lymphatic Drainage of the Splenic Flexure: Towards a Patient-Specific Surgical Approach for Splenic Flexure Cancer.ANZ journal of surgery · 2025Article
- Prognostic impact of lateral sentinel lymph node biopsy using indocyanine green on oncological outcomes for clinical stage II/III lower rectal cancer without suspected lateral lymph node metastasis.Langenbeck's archives of surgery · 2024Article
- Indocyanine green guided sentinel lymph node biopsy may have a high sensitivity for early (T1/T2) colon cancer: A prospective study in Indian patients.Turkish journal of surgery · 2023Article
- Review
- Real-time fluorescence image-guided gastrointestinal oncologic surgery: Towards a new era.World journal of gastrointestinal oncology · 2021Review
- The Value of Sentinel Lymph Node Mapping for the Staging of Node-Negative Colon Cancer: Propensity Score and Mediation Analyses.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2021Article
- Predictive value of the sentinel lymph node procedure in the staging of non-metastatic colorectal cancer.International journal of colorectal disease · 2020Article
- Comprehensive literature review of randomized clinical trials examining novel treatment advances in patients with colon cancer.Journal of gastrointestinal oncology · 2020Review
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Authors and funding
28 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe clinical impact of sentinel lymph node biopsy (SLNB) in colon cancer is still controversial. The purpose of this prospective multicenter trial was to evaluate its clinical value to predict the nodal status and identify factors that influence these results.
methodsColon cancer patients without prior colorectal surgery or irradiation were eligible. The sentinel lymph node (SLN) was identified intraoperatively by subserosal blue dye injection around the tumor. The SLN underwent step sections and immunohistochemistry (IHC), if classified free of metastases after routine hematoxylin and eosin examination.
resultsAt least one SLN (median, n = 2) was identified in 268 of 315 enrolled patients (detection rate, 85%). Center experience, lymphovascular invasion, body mass index (BMI), and learning curve were positively associated with the detection rate. The false-negative rate to identify pN+ patients by SLNB was 46% (38 of 82). BMI showed a significant association to the false-negative rate (P < 0.0001), the number of tumor-involved lymph nodes was inversely associated. If only slim patients (BMI < or =24) were investigated in experienced centers (>22 patients enrolled), the sensitivity increased to 88% (14 of 16). Moreover, 21% (30 of 141) of the patients, classified as pN0 by routine histopathology, revealed micrometastases or isolated tumor cells (MM/ITC) in the SLN.
conclusionsThe contribution of SLNB to conventional nodal staging of colon cancer patients is still unspecified. Technical problems have to be resolved before a definite conclusion can be drawn in this regard. However, SLNB identifies about one fourth of stage II patients to reveal MM/ITC in lymph nodes. Further studies must clarify the clinical impact of these findings in terms of prognosis and the indication of adjuvant therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.