ArticleNeuro-oncology2007
Expression of the neurogenic basic helix-loop-helix transcription factor NEUROG1 identifies a subgroup of medulloblastomas not expressing ATOH1.
Article in Neuro-oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects.Molecular oncology · 2026Article
- Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastoma.Nature communications · 2025Article
- A transcriptome-based classifier to determine molecular subtypes in medulloblastoma.PLoS computational biology · 2020Article
- Zebrin II Is Ectopically Expressed in Microglia in the Cerebellum of Neurogenin 2 Null Mice.Cerebellum (London, England) · 2019Article
- Article
- Novel gene expression model for outcome prediction in paediatric medulloblastoma.Journal of molecular neuroscience : MN · 2013Article
- Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.Genes & development · 2012Article
- FABP4 is a candidate marker of cerebellar liponeurocytomas.Journal of neuro-oncology · 2012Article
- Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.Cancer cell · 2012Article
- Pattern formation during development of the embryonic cerebellum.Frontiers in neuroanatomy · 2012Article
- Expression profile of frizzled receptors in human medulloblastomas.Journal of neuro-oncology · 2012Article
- The genesis of cerebellar GABAergic neurons: fate potential and specification mechanisms.Frontiers in neuroanatomy · 2012Article
- The compartmental restriction of cerebellar interneurons.Frontiers in neural circuits · 2012Article
- Intracranial orthotopic allografting of medulloblastoma cells in immunocompromised mice.Journal of visualized experiments : JoVE · 2010Article
- Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective.Neuro-oncology · 2008Review
- Just say no to ATOH: how HIC1 methylation might predispose medulloblastoma to lineage addiction.Cancer research · 2008Review
- Differential expression and prognostic significance of SOX genes in pediatric medulloblastoma and ependymoma identified by microarray analysis.Neuro-oncology · 2008Article
- Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.Cancer cell · 2008Article
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8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To gain insight into the lineage of origin of medulloblastomas, the mRNA expression of NEUROG1, a gene encoding a proneural transcription factor transiently detected during nervous system development, was investigated in 27 human medulloblastomas characterized for mRNA expression of ATOH1, a marker of cerebellar granule precursors and corresponding medulloblastomas. Expression of Ngn1, the mouse homolog of NEUROG1, was also analyzed in the mouse cerebellar primordium. In addition, we studied mRNA expression of GLI1 as a marker of the SHH pathway activation, and nuclear beta-catenin staining, beta-catenin mutations, and mRNA expression of MYC as indicators of the WNT pathway status. In 15 cases, we also examined expression of OTX2, a transcription factor recently indicated as a positive marker of medulloblastomas originating from cerebellar granule precursors. The mRNA expression of NEUROG1 and Ngn1 was selectively found in medulloblastomas not expressing ATOH1 and in progenitors of the cerebellar ventricular zone, respectively. GLI1 transcript was expressed in medulloblastomas with ATOH1 transcript, whereas high levels of MYC transcript were unrelated to NEUROG1 or ATOH1 expression. No clear association between MYC overexpression and nuclear beta-catenin staining was found. Finally, OTX2 mRNA was expressed in all medulloblastomas with NEUROG1 transcript, but also in a subset of these malignancies with ATOH1 transcript. These observations may help to define the lineage of origin of medulloblastomas, and support a role for ATOH1 and NEUROG1 in the classification of these malignancies.
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