ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Cholinergic modulation of spindle bursts in the neonatal rat visual cortex in vivo.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Changing subplate circuits: Early activity dependent circuit plasticity.Frontiers in cellular neuroscience · 2022Pooled it
- Interneurons and network activity in the cerebral cortex: a developmental dialogue.Nature reviews. Neuroscience · 2026Review
- A topographic protomap in mouse subplate neurons precedes the onset of sensory experience.Nature communications · 2026Article
- Pharmacological manipulation of nested oscillations in human iPSC-derived 2D neuronal networks.Neurobiology of disease · 2026Article
- Development of spontaneous and sensory evoked network activity in rodent cerebral cortexFrontiers in cellular neuroscience · 2025Review
- Network state transitions during cortical development.Nature reviews. Neuroscience · 2024Review
- Is Autonomic Nervous System Involved in the Epileptogenesis in Preterm Neonates?Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- Article
- Sleep, plasticity, and sensory neurodevelopment.Neuron · 2022Review
- Development of prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Prognostic value of neonatal EEG following therapeutic hypothermia in survivors of hypoxic-ischemic encephalopathy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- A Neonatal Mild Defect in Brain Insulin Signaling Predisposes a Subclinical Model of Sporadic Alzheimer's to Develop the Disease.Journal of molecular neuroscience : MN · 2021Article
- Oxytocin Shapes Spontaneous Activity Patterns in the Developing Visual Cortex by Activating Somatostatin Interneurons.Current biology : CB · 2021Article
- THE DEVELOPING BRAIN REVEALED DURING SLEEP.Current opinion in physiology · 2020Article
- Active Sleep Promotes Coherent Oscillatory Activity in the Cortico-Hippocampal System of Infant Rats.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Emergence of Coordinated Activity in the Developing Entorhinal-Hippocampal Network.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Bilateral Synchronization of Hippocampal Early Sharp Waves in Neonatal Rats.Frontiers in cellular neuroscience · 2019Article
- The Superior Function of the Subplate in Early Neocortical Development.Frontiers in neuroanatomy · 2018Review
- Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks.Nature communications · 2017Article
- Modulation of Neocortical Development by Early Neuronal Activity: Physiology and Pathophysiology.Frontiers in cellular neuroscience · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylcholine (ACh) is known to shape the adult neocortical activity related to behavioral states and processing of sensory information. However, the impact of cholinergic input on the neonatal neuronal activity remains widely unknown. Early during development, the principal activity pattern in the primary visual (V1) cortex is the intermittent self-organized spindle burst oscillation that can be driven by the retinal waves. Here, we assessed the relationship between this early activity pattern and the cholinergic drive by either blocking or augmenting the cholinergic input and investigating the resultant effects on the activity of the rat visual cortex during the first postnatal week in vivo. Blockade of the muscarinic receptors by intracerebroventricular, intracortical, or supracortical atropine application decreased the occurrence of V1 spindle bursts by 50%, both the retina-independent and the optic nerve-mediated spindle bursts being affected. In contrast, blockade of acetylcholine esterase with physostigmine augmented the occurrence, amplitude, and duration of V1 spindle bursts. Whereas direct stimulation of the cholinergic basal forebrain nuclei increased the occurrence probability of V1 spindle bursts, their chronic immunotoxic lesion using 192 IgG-saporin decreased the occurrence of neonatal V1 oscillatory activity by 87%. Thus, the cholinergic input facilitates the neonatal V1 spindle bursts and may prime the developing cortex to operate specifically on relevant early (retinal waves) and later (visual input) stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.