ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Multiple modes of synaptic excitation of olfactory bulb granule cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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Who cites it
108 citing papers in PubMed, 171 citations in OpenAlex.
- Synaptic Inhibition in the Accessory Olfactory Bulb Regulates Pheromone Location Learning and Memory.FASEB bioAdvances · 2026Article
- Early and Late Phases of Sensory-Evoked Olfactory Bulb Inhibition Are Mediated by Parallel Local Circuits: Attenuation of Fast Tufted Cell Axo-dendritic Inputs to Granule Cells by Adenosine A1 Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Physiopathology of nasal and ecnomotopic olfactory receptors: focus on molecular pathways and potential pharmacological modulation.Frontiers in pharmacology · 2026Review
- Cell type-specific and frequency-dependent centrifugal modulation in olfactory bulb output neurons in vivo.Journal of neurophysiology · 2024Article
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
- Value-related learning in the olfactory bulb occurs through pathway-dependent perisomatic inhibition of mitral cells.PLoS biology · 2024Article
- Frequency-dependent centrifugal modulation of the activity of different classes of mitral and tufted cells in olfactory bulb.Journal of neurophysiology · 2023Article
- Organizational Principles of the Centrifugal Projections to the Olfactory Bulb.International journal of molecular sciences · 2023Article
- Bulbar projecting subcortical GABAergic neurons send collateral branches extensively and selectively to primary olfactory cortical regions.The Journal of comparative neurology · 2023Article
- Neuronal Adenosine AFrontiers in cellular neuroscience · 2022Article
- Choline Transporter regulates olfactory habituation via a neuronal triad of excitatory, inhibitory and mushroom body neurons.PLoS genetics · 2021Article
- Cortical feedback and gating in odor discrimination and generalization.PLoS computational biology · 2021Article
- Olfactory Optogenetics: Light Illuminates the Chemical Sensing Mechanisms of Biological Olfactory Systems.Biosensors · 2021Review
- Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Short-Term Plasticity in Cortical GABAergic Synapses on Olfactory Bulb Granule Cells Is Modulated by Endocannabinoids.Frontiers in cellular neuroscience · 2021Article
- Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models.Current research in neurobiology · 2021Review
- An Evolutionary Microcircuit Approach to the Neural Basis of High Dimensional Sensory Processing in Olfaction.Frontiers in cellular neuroscience · 2021Article
- Extrinsic neuromodulation in the rodent olfactory bulb.Cell and tissue research · 2021Review
- Activation of Granule Cell Interneurons by Two Divergent Local Circuit Pathways in the Rat Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- CCKergic Tufted Cells Differentially Drive Two Anatomically Segregated Inhibitory Circuits in the Mouse Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
48 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Inhibition generated by granule cells, the most common GABAergic cell type in the olfactory bulb, plays a critical role in shaping the output of the olfactory bulb. However, relatively little is known about the synaptic mechanisms responsible for activating these interneurons in addition to the specialized dendrodendritic synapses located on distal dendrites. Using two-photon guided minimal stimulation in acute rat brain slices, we found that distal and proximal excitatory synapses onto granule cells are functionally distinct. Proximal synapses arise from piriform cortical neurons and facilitate with paired-pulse stimulation, whereas distal dendrodendritic synapses generate EPSCs with slower kinetics that depress with paired stimulation. Proximal cortical feedback inputs can relieve the tonic Mg block of NMDA receptors (NMDARs) at distal synapses and gate dendrodendritic inhibition onto mitral cells. Most excitatory synapses we examined onto granule cells activated both NMDARs and AMPA receptors, whereas a subpopulation appeared to be NMDAR silent. The convergence of two types of excitatory inputs onto GABAergic granule cells provides a novel mechanism for regulating the degree of interglomerular processing of sensory input in the olfactory bulb through piriform cortex/olfactory bulb synaptic interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.