ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Translocation of Gq alpha mediates long-term adaptation in Drosophila photoreceptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- A Single Residue Mutation in the GαG3 (Bethesda, Md.) · 2018Article
- Ectopic Expression of Mouse Melanopsin inThe Journal of biological chemistry · 2017Article
- Guanine nucleotide-binding protein (Gα) endocytosis by a cascade of ubiquitin binding domain proteins is required for sustained morphogenesis and proper mating in yeast.The Journal of biological chemistry · 2014Article
- What the clock tells the eye: lessons from an ancient arthropod.Integrative and comparative biology · 2013Review
- Opsin1-2, G(q)α and arrestin levels at Limulus rhabdoms are controlled by diurnal light and a circadian clock.The Journal of experimental biology · 2013Article
- Stochastic, adaptive sampling of information by microvilli in fly photoreceptors.Current biology : CB · 2012Article
- Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Simple ways to measure behavioral responses of Drosophila to stimuli and use of these methods to characterize a novel mutant.PloS one · 2012Article
- G protein trafficking.Sub-cellular biochemistry · 2012Review
- Retinophilin is a light-regulated phosphoprotein required to suppress photoreceptor dark noise in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- G protein subunit dissociation and translocation regulate cellular response to receptor stimulation.PloS one · 2009Article
- Overexpressing temperature-sensitive dynamin decelerates phototransduction and bundles microtubules in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Prolonged illumination up-regulates arrestin and two guanylate cyclase activating proteins: a novel mechanism for light adaptation.The Journal of physiology · 2009Article
- Role of Ca2+/calmodulin-dependent protein kinase II in Drosophila photoreceptors.The Journal of biological chemistry · 2009Article
- Drosophila photoreceptors and signaling mechanisms.Frontiers in cellular neuroscience · 2009Article
- Mutation of a TADR protein leads to rhodopsin and Gq-dependent retinal degeneration in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Light adaptation is a process that enables photoreceptor cells to operate over a wide range of light intensities without saturation. In invertebrate photoreceptors, fast adaptation is mediated by a Ca2+-dependent negative-feedback mechanism, which mainly affects the terminal steps of the cascade. Therefore, the response to each photon is smaller as light intensity increases, accommodating both high sensitivity and a vast dynamic range. Here, we describe a novel type of adaptation, which is mediated by one of the first steps in the phototransduction cascade affecting the sensitivity to absorbed photons. Long exposure to light resulted in dramatic reduction in the probability of each absorbed photon to elicit a response, whereas the size and shape of each single photon response did not change. To dissect the molecular mechanism underlying this form of adaptation we used a series of Drosophila mutants. Genetic dissection showed a pivotal role for light-induced translocation of Gq alpha between the signaling membrane and the cytosol. Biochemical studies revealed that the sensitivity to light depends on membrane Gq alpha concentration, which was modulated either by light or by mutations that impaired its targeting to the membrane. We conclude that long-term adaptation is mediated by the movement of Gq alpha from the signaling membrane to the cytosol, thereby reducing the probability of each photon to elicit a response. The slow time scale of this adaptation fits well with day/night light intensity changes, because there is no need to maintain single photon sensitivity during daytime.
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